Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to Bedside
About 17 million people worldwide live with cerebral palsy, the most common disability in childhood, with hypoxic-ischemic encephalopathy, preterm birth, and low birth weight being the most important risk factors. This review will focus on recent developments in cell therapy for infantile cerebral p...
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Wiley
2014-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2014/976321 |
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| author | A. Jensen |
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| collection | DOAJ |
| description | About 17 million people worldwide live with cerebral palsy, the most common disability in childhood, with hypoxic-ischemic encephalopathy, preterm birth, and low birth weight being the most important risk factors. This review will focus on recent developments in cell therapy for infantile cerebral palsy by transplantation of autologous umbilical cord blood. There are only 4 publications available at present; however, the observations made along with experimental data in vivo and in vitro may be of utmost importance clinically, so that a review at an early developmental stage of this new therapeutic concept seems justified. Particularly, since the first published double-blind randomized placebo-controlled trial in a paradigm using allogeneic cord blood and erythropoietin to treat cerebral palsy under immunosuppression showed beneficial therapeutic effects in infantile cerebral palsy, long-held doubts about the efficacy of this new cell therapy are dispelled and a revision of therapeutic views upon an ailment, for which there is no cure at present, is warranted. Hence, this review will summarize the available information on autologous cord blood therapy for cerebral palsy and that on the relevant experimental work as far as potential mechanisms and modes of action are concerned. |
| format | Article |
| id | doaj-art-e3095a77a5b64e46a4d244a6e3497085 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-e3095a77a5b64e46a4d244a6e34970852025-02-03T06:00:19ZengWileyObstetrics and Gynecology International1687-95891687-95972014-01-01201410.1155/2014/976321976321Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to BedsideA. Jensen0Campus Clinic Gynecology, Ruhr-University Bochum, Universitätsstraße 140, 44799 Bochum, GermanyAbout 17 million people worldwide live with cerebral palsy, the most common disability in childhood, with hypoxic-ischemic encephalopathy, preterm birth, and low birth weight being the most important risk factors. This review will focus on recent developments in cell therapy for infantile cerebral palsy by transplantation of autologous umbilical cord blood. There are only 4 publications available at present; however, the observations made along with experimental data in vivo and in vitro may be of utmost importance clinically, so that a review at an early developmental stage of this new therapeutic concept seems justified. Particularly, since the first published double-blind randomized placebo-controlled trial in a paradigm using allogeneic cord blood and erythropoietin to treat cerebral palsy under immunosuppression showed beneficial therapeutic effects in infantile cerebral palsy, long-held doubts about the efficacy of this new cell therapy are dispelled and a revision of therapeutic views upon an ailment, for which there is no cure at present, is warranted. Hence, this review will summarize the available information on autologous cord blood therapy for cerebral palsy and that on the relevant experimental work as far as potential mechanisms and modes of action are concerned.http://dx.doi.org/10.1155/2014/976321 |
| spellingShingle | A. Jensen Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to Bedside Obstetrics and Gynecology International |
| title | Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to Bedside |
| title_full | Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to Bedside |
| title_fullStr | Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to Bedside |
| title_full_unstemmed | Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to Bedside |
| title_short | Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to Bedside |
| title_sort | autologous cord blood therapy for infantile cerebral palsy from bench to bedside |
| url | http://dx.doi.org/10.1155/2014/976321 |
| work_keys_str_mv | AT ajensen autologouscordbloodtherapyforinfantilecerebralpalsyfrombenchtobedside |