HCV and Lymphoproliferation
Hepatitis C virus (HCV) infection is a serious public health problem because of its worldwide diffusion and sequelae. It is not only a hepatotropic but also a lymphotropic agent and is responsible not only for liver injury—potentially evolving to cirrhosis and hepatocellular carcinoma—but also for a...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/980942 |
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| _version_ | 1832560005719523328 |
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| author | Anna Linda Zignego Carlo Giannini Laura Gragnani |
| author_facet | Anna Linda Zignego Carlo Giannini Laura Gragnani |
| author_sort | Anna Linda Zignego |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) infection is a serious public health problem because of its worldwide diffusion and sequelae. It is not only a hepatotropic but also a lymphotropic agent and is responsible not only for liver injury—potentially evolving to cirrhosis and hepatocellular carcinoma—but also for a series of sometimes severely disabling extrahepatic diseases and, in particular, B-cell lymphoproliferative disorders. These latter range from benign, but prelymphomatous conditions, like mixed cryoglobulinemia, to frank lymphomas. Analogously with Helicobacter pylori related lymphomagenesis, the study of the effects of viral eradication confirmed the etiopathogenetic role of HCV and showed it is an ideal model for better understanding of the molecular mechanisms involved. Concerning these latter, several hypotheses have been proposed over the past two decades which are not mutually exclusive. These hypotheses have variously emphasized the important role played by sustained stimulation of the immune system by HCV, infection of the lymphatic cells, viral proteins, chromosomal aberrations, cytokines, or microRNA molecules. In this paper we describe the main hypotheses that have been proposed with the corresponding principal supporting data. |
| format | Article |
| id | doaj-art-e3080147b5df4900bb0db11cd81bf9a1 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e3080147b5df4900bb0db11cd81bf9a12025-02-03T01:28:41ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/980942980942HCV and LymphoproliferationAnna Linda Zignego0Carlo Giannini1Laura Gragnani2Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Internal Medicine, University of Florence, 50134 Florence, ItalyCenter for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Internal Medicine, University of Florence, 50134 Florence, ItalyCenter for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Internal Medicine, University of Florence, 50134 Florence, ItalyHepatitis C virus (HCV) infection is a serious public health problem because of its worldwide diffusion and sequelae. It is not only a hepatotropic but also a lymphotropic agent and is responsible not only for liver injury—potentially evolving to cirrhosis and hepatocellular carcinoma—but also for a series of sometimes severely disabling extrahepatic diseases and, in particular, B-cell lymphoproliferative disorders. These latter range from benign, but prelymphomatous conditions, like mixed cryoglobulinemia, to frank lymphomas. Analogously with Helicobacter pylori related lymphomagenesis, the study of the effects of viral eradication confirmed the etiopathogenetic role of HCV and showed it is an ideal model for better understanding of the molecular mechanisms involved. Concerning these latter, several hypotheses have been proposed over the past two decades which are not mutually exclusive. These hypotheses have variously emphasized the important role played by sustained stimulation of the immune system by HCV, infection of the lymphatic cells, viral proteins, chromosomal aberrations, cytokines, or microRNA molecules. In this paper we describe the main hypotheses that have been proposed with the corresponding principal supporting data.http://dx.doi.org/10.1155/2012/980942 |
| spellingShingle | Anna Linda Zignego Carlo Giannini Laura Gragnani HCV and Lymphoproliferation Clinical and Developmental Immunology |
| title | HCV and Lymphoproliferation |
| title_full | HCV and Lymphoproliferation |
| title_fullStr | HCV and Lymphoproliferation |
| title_full_unstemmed | HCV and Lymphoproliferation |
| title_short | HCV and Lymphoproliferation |
| title_sort | hcv and lymphoproliferation |
| url | http://dx.doi.org/10.1155/2012/980942 |
| work_keys_str_mv | AT annalindazignego hcvandlymphoproliferation AT carlogiannini hcvandlymphoproliferation AT lauragragnani hcvandlymphoproliferation |