Age-Related Modifications in Circulating IL-15 Levels in Humans
Aging is associated to a progressive establishing of a chronic inflammatory state linked to a continuous long exposure to antigens. Since IL-15 stimulates the proliferation of memory T cells and the immunosenescence is characterized by accumulation of memory T cells and exhaustion of naive T cells,...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.245 |
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| _version_ | 1832558968635916288 |
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| author | Sebastiano Gangemi Giorgio Basile Daniela Monti Rosaria Alba Merendino Giuseppe Di Pasquale Ursula Bisignano Vittorio Nicita-Mauro Claudio Franceschi |
| author_facet | Sebastiano Gangemi Giorgio Basile Daniela Monti Rosaria Alba Merendino Giuseppe Di Pasquale Ursula Bisignano Vittorio Nicita-Mauro Claudio Franceschi |
| author_sort | Sebastiano Gangemi |
| collection | DOAJ |
| description | Aging is associated to a progressive establishing of a chronic inflammatory state linked to a continuous long exposure to antigens. Since IL-15 stimulates the proliferation of memory T cells and the immunosenescence is characterized by accumulation of memory T cells and exhaustion of naive T cells, we analyzed IL-15 levels in sera from 30 ultralongeval subjects with respect to those from young and old adults. IL-15 levels were assayed by immunoenzymatic methods. Ultralongeval subjects displayed significantly higher IL-15 levels with respect to both young and old controls. No statistical difference was found between old and young controls. These findings may explain, at least in part, the characteristic increase of memory cells in immunosenescence and the capacity of the immune system of centenarians to defend itself from infections through immune-inflammatory responses. |
| format | Article |
| id | doaj-art-e3068b4c99fb4899bd43eb8701683005 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e3068b4c99fb4899bd43eb87016830052025-02-03T01:31:09ZengWileyMediators of Inflammation0962-93511466-18612005-01-012005424524710.1155/MI.2005.245Age-Related Modifications in Circulating IL-15 Levels in HumansSebastiano Gangemi0Giorgio Basile1Daniela Monti2Rosaria Alba Merendino3Giuseppe Di Pasquale4Ursula Bisignano5Vittorio Nicita-Mauro6Claudio Franceschi7Department of Human Pathology, School of Allergy and Clinical Immunology, University of Messina, Messina 98125, ItalyDepartment of Internal Medicine, Division of Geriatric Medicine, University of Messina, Messina 98125, ItalyDepartment of Experimental Oncological Pathology, University of Florence, Tuscany, 50134, ItalyDepartment of Human Pathology, School of Allergy and Clinical Immunology, University of Messina, Messina 98125, ItalyDepartment of Internal Medicine, University of Messina, Messina 98125, ItalyDepartment of Internal Medicine, University of Messina, Messina 98125, ItalyDepartment of Internal Medicine, Division of Geriatric Medicine, University of Messina, Messina 98125, ItalyInterdepartmental Center “L. Galvani” for Integrated Studies on Bioinformatics, Biophysics, and Biocomplexity, University of Bologna, Bologna 40100, ItalyAging is associated to a progressive establishing of a chronic inflammatory state linked to a continuous long exposure to antigens. Since IL-15 stimulates the proliferation of memory T cells and the immunosenescence is characterized by accumulation of memory T cells and exhaustion of naive T cells, we analyzed IL-15 levels in sera from 30 ultralongeval subjects with respect to those from young and old adults. IL-15 levels were assayed by immunoenzymatic methods. Ultralongeval subjects displayed significantly higher IL-15 levels with respect to both young and old controls. No statistical difference was found between old and young controls. These findings may explain, at least in part, the characteristic increase of memory cells in immunosenescence and the capacity of the immune system of centenarians to defend itself from infections through immune-inflammatory responses.http://dx.doi.org/10.1155/MI.2005.245 |
| spellingShingle | Sebastiano Gangemi Giorgio Basile Daniela Monti Rosaria Alba Merendino Giuseppe Di Pasquale Ursula Bisignano Vittorio Nicita-Mauro Claudio Franceschi Age-Related Modifications in Circulating IL-15 Levels in Humans Mediators of Inflammation |
| title | Age-Related Modifications in Circulating IL-15 Levels in Humans |
| title_full | Age-Related Modifications in Circulating IL-15 Levels in Humans |
| title_fullStr | Age-Related Modifications in Circulating IL-15 Levels in Humans |
| title_full_unstemmed | Age-Related Modifications in Circulating IL-15 Levels in Humans |
| title_short | Age-Related Modifications in Circulating IL-15 Levels in Humans |
| title_sort | age related modifications in circulating il 15 levels in humans |
| url | http://dx.doi.org/10.1155/MI.2005.245 |
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