Adoptive transfer of membrane-restricted IL-12-TCR T cells promotes antigen spreading and elimination of antigen-negative tumor variants

Adoptive transfer of membrane-restricted IL-12-TCR T cells promotes antigen spreading and elimination of antigen-negative tumor variants

Background Adoptive T-cell therapy has demonstrated clinical activity in B-cell malignancies, offering hope for its application to a broad spectrum of cancers. However, a significant portion of patients with solid tumors experience primary or secondary resistance to this treatment modality. Target a...

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Main Authors: James L Gulley, Ling Zhang, Christian S Hinrichs, John S Davies, Andrew Sinkoe, Wiem Lassoued, Farrah Karimipour, Philip Homan, Daniel Burnett, Scott M Norberg, Alex Kuznetsov, Margaret Cam, Ping Xue
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/11/e009868.full
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