Single-cell and transcriptome analyses revealed CTHRC1 a potential therapeutic target mediating invasion and tumor microenvironment in TNBC: experimental validation

Single-cell and transcriptome analyses revealed CTHRC1 a potential therapeutic target mediating invasion and tumor microenvironment in TNBC: experimental validation

BackgroundInvestigating the pivotal role of CTHRC1 in the tumor microenvironment of triple-negative breast cancer (TNBC).MethodThe RNA transcriptomic data obtained from the Cancer Genome Atlas and single-cell sequencing data from TNBC in Gene Expression Omnibus (GEO) were acquired and subjected to a...

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Bibliographic Details
Main Authors: Hong Wan, Zichen Ling, Yuwei Xie, Han Jiang, Zhifan Ruan, Dashuai Yang, Xiaowei Yang, Jing Pei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
TNBC
invasion
CAFs
tumor microenvironment
M2-type macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534981/full
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