EMCDDA Framework for Naming Cathinones
Introduction: The short names attributed to the 170 cathinones monitored by the EMCDDA are only loosely associated with structural features. Although related to the parent compound cathinone, one of the psychoactive principals in khat, attributing consistent, informative, and user-friendly common na...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Emerging Trends in Drugs, Addictions, and Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266711822300065X |
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| author | B. Pulver S. Fischmann A. Gallegos R. Christie |
| author_facet | B. Pulver S. Fischmann A. Gallegos R. Christie |
| author_sort | B. Pulver |
| collection | DOAJ |
| description | Introduction: The short names attributed to the 170 cathinones monitored by the EMCDDA are only loosely associated with structural features. Although related to the parent compound cathinone, one of the psychoactive principals in khat, attributing consistent, informative, and user-friendly common names to these substances is challenging. Methods: Current naming approaches were reviewed and common structural features of cathinones identified, for which abbreviations were derived from organic chemistry nomenclature and current names. Results: An EMCDDA naming framework based on the main motifs ‘cathinone’ and ‘phenone’ was developed by incorporating earlier naming approaches. The framework name of each cathinone is composed of a parent element, which, combined with information on the keto alkyl chain or the amine substitution, yields the principal name. Additional substitutions are prepended to the principal name. Other parent elements besides the two main motifs (e.g., naphthalen-2-yl) are included in the naming framework. The framework also provides exceptions for several cathinones scheduled under UN and EU legislation and structural analogs (e.g. mephedrone/4 MMC/4-methylmethcathinone). Conclusions: The EMCDDA framework on naming cathinones provides practical guidance through examples and explanations of the rationale on how consistent semi-systematic names can be derived. Owing to the structural diversity of NPS, the forensic community, researchers, and policy makers widely recognize the need for harmonized naming to achieve consensus in the denomination of NPS in legislative texts and scientific dialogue. |
| format | Article |
| id | doaj-art-e2fd2997afcb420f8fdb36cbc5d3342d |
| institution | OA Journals |
| issn | 2667-1182 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Emerging Trends in Drugs, Addictions, and Health |
| spelling | doaj-art-e2fd2997afcb420f8fdb36cbc5d3342d2025-08-20T01:56:34ZengElsevierEmerging Trends in Drugs, Addictions, and Health2667-11822024-12-01410011410.1016/j.etdah.2023.100114EMCDDA Framework for Naming CathinonesB. Pulver0S. Fischmann1A. Gallegos2R. Christie3Institute of Forensic Medicine, Forensic Toxicology, Medical Center, University of Freiburg, GermanyInstitute of Forensic Medicine, Forensic Toxicology, Medical Center, University of Freiburg, GermanyInstitute of Forensic Medicine, Forensic Toxicology, Medical Center, University of Freiburg, GermanyInstitute of Forensic Medicine, Forensic Toxicology, Medical Center, University of Freiburg, GermanyIntroduction: The short names attributed to the 170 cathinones monitored by the EMCDDA are only loosely associated with structural features. Although related to the parent compound cathinone, one of the psychoactive principals in khat, attributing consistent, informative, and user-friendly common names to these substances is challenging. Methods: Current naming approaches were reviewed and common structural features of cathinones identified, for which abbreviations were derived from organic chemistry nomenclature and current names. Results: An EMCDDA naming framework based on the main motifs ‘cathinone’ and ‘phenone’ was developed by incorporating earlier naming approaches. The framework name of each cathinone is composed of a parent element, which, combined with information on the keto alkyl chain or the amine substitution, yields the principal name. Additional substitutions are prepended to the principal name. Other parent elements besides the two main motifs (e.g., naphthalen-2-yl) are included in the naming framework. The framework also provides exceptions for several cathinones scheduled under UN and EU legislation and structural analogs (e.g. mephedrone/4 MMC/4-methylmethcathinone). Conclusions: The EMCDDA framework on naming cathinones provides practical guidance through examples and explanations of the rationale on how consistent semi-systematic names can be derived. Owing to the structural diversity of NPS, the forensic community, researchers, and policy makers widely recognize the need for harmonized naming to achieve consensus in the denomination of NPS in legislative texts and scientific dialogue.http://www.sciencedirect.com/science/article/pii/S266711822300065X |
| spellingShingle | B. Pulver S. Fischmann A. Gallegos R. Christie EMCDDA Framework for Naming Cathinones Emerging Trends in Drugs, Addictions, and Health |
| title | EMCDDA Framework for Naming Cathinones |
| title_full | EMCDDA Framework for Naming Cathinones |
| title_fullStr | EMCDDA Framework for Naming Cathinones |
| title_full_unstemmed | EMCDDA Framework for Naming Cathinones |
| title_short | EMCDDA Framework for Naming Cathinones |
| title_sort | emcdda framework for naming cathinones |
| url | http://www.sciencedirect.com/science/article/pii/S266711822300065X |
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