Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer
Studies focusing on gender have shown that differences exist in how the immune system responds to disease and therapy. Understanding how gender influences immunological mechanisms in health and disease and identifying gender-specific biomarkers could lead to specifically tailored treatment and ultim...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/819724 |
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| author | Patrizia Pellegrini Ida Contasta Tiziana Del Beato Fabiana Ciccone Anna Maria Berghella |
| author_facet | Patrizia Pellegrini Ida Contasta Tiziana Del Beato Fabiana Ciccone Anna Maria Berghella |
| author_sort | Patrizia Pellegrini |
| collection | DOAJ |
| description | Studies focusing on gender have shown that differences exist in how the immune system responds to disease and therapy. Understanding how gender influences immunological mechanisms in health and disease and identifying gender-specific biomarkers could lead to specifically tailored treatment and ultimately improve therapeutic success rates. T helper1 (Th1) and Th2 cytokines (Th1/Th2) have pivotal roles in the homeostasis of Th1 and Th2 cell network functions in the immune response but sex steroids affect Th1/Th2 production in different ways and a natural sexual dimorphism in the immune response has been shown. In order to investigate these differences further, we developed Th-cytokine data-driven models of the immune response and evaluated healthy subject peripheral blood samples. Independent cohorts of colorectal cancer and adenoma patients were also studied for comparison purposes. Our results show that the interferon (IFN)γ production pathway for immune response homeostasis is specific to men whilst the interleukin- (IL-) 6 production pathway for immune response homeostasis is specific to women. The IL-10 pathway for restoring immune system resting homeostasis was common to both but was controlled by the respective gender-specific pathways. These gender pathways could well be used as targets and biomarkers in translational research into developing new clinical strategies. |
| format | Article |
| id | doaj-art-e2fa33ad289a46f7ad59a019e6a293d2 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e2fa33ad289a46f7ad59a019e6a293d22025-02-03T05:54:06ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/819724819724Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal CancerPatrizia Pellegrini0Ida Contasta1Tiziana Del Beato2Fabiana Ciccone3Anna Maria Berghella4National Council of Research (CNR), Institute of Translational Pharmacology (IFT), 67100 L'Aquila, ItalyNational Council of Research (CNR), Institute of Translational Pharmacology (IFT), 67100 L'Aquila, ItalyNational Council of Research (CNR), Institute of Translational Pharmacology (IFT), 67100 L'Aquila, ItalyNational Council of Research (CNR), Institute of Translational Pharmacology (IFT), 67100 L'Aquila, ItalyNational Council of Research (CNR), Institute of Translational Pharmacology (IFT), 67100 L'Aquila, ItalyStudies focusing on gender have shown that differences exist in how the immune system responds to disease and therapy. Understanding how gender influences immunological mechanisms in health and disease and identifying gender-specific biomarkers could lead to specifically tailored treatment and ultimately improve therapeutic success rates. T helper1 (Th1) and Th2 cytokines (Th1/Th2) have pivotal roles in the homeostasis of Th1 and Th2 cell network functions in the immune response but sex steroids affect Th1/Th2 production in different ways and a natural sexual dimorphism in the immune response has been shown. In order to investigate these differences further, we developed Th-cytokine data-driven models of the immune response and evaluated healthy subject peripheral blood samples. Independent cohorts of colorectal cancer and adenoma patients were also studied for comparison purposes. Our results show that the interferon (IFN)γ production pathway for immune response homeostasis is specific to men whilst the interleukin- (IL-) 6 production pathway for immune response homeostasis is specific to women. The IL-10 pathway for restoring immune system resting homeostasis was common to both but was controlled by the respective gender-specific pathways. These gender pathways could well be used as targets and biomarkers in translational research into developing new clinical strategies.http://dx.doi.org/10.1155/2011/819724 |
| spellingShingle | Patrizia Pellegrini Ida Contasta Tiziana Del Beato Fabiana Ciccone Anna Maria Berghella Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer Clinical and Developmental Immunology |
| title | Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer |
| title_full | Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer |
| title_fullStr | Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer |
| title_full_unstemmed | Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer |
| title_short | Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer |
| title_sort | gender specific cytokine pathways targets and biomarkers for the switch from health to adenoma and colorectal cancer |
| url | http://dx.doi.org/10.1155/2011/819724 |
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