The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease
Current data suggests that statins might have beneficial effects on renal outcomes. Beneficial effects of statin treatment on renal progression in advanced chronic kidney disease (CKD) are obviously controversial. In a retrospective, controlled study, the authors have evaluated the effects of 53-wee...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2015/485839 |
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| author | Bancha Satirapoj Anan Promrattanakun Ouppatham Supasyndh Panbuppa Choovichian |
| author_facet | Bancha Satirapoj Anan Promrattanakun Ouppatham Supasyndh Panbuppa Choovichian |
| author_sort | Bancha Satirapoj |
| collection | DOAJ |
| description | Current data suggests that statins might have beneficial effects on renal outcomes. Beneficial effects of statin treatment on renal progression in advanced chronic kidney disease (CKD) are obviously controversial. In a retrospective, controlled study, the authors have evaluated the effects of 53-week treatment with simvastatin, versus no treatment on proteinuria and renal function among 51 patients with CKD stages III-IV. By the end of the 53-week treatment, urine protein excretion decreased from 0.96 (IQR 0.54, 2.9) to 0.48 (IQR 0.18, 0.79) g/g creatinine (P<0.001) in patients treated with simvastatin in addition to ACEI and ARBs, while no change was observed among the untreated patients. Moreover, a significantly greater decrease in urine protein excretion was observed in the simvastatin group as compared with the untreated group. The mean changes of serum creatinine and eGFR did not significantly differ in both groups. A significantly greater decrease in total cholesterol and LDL-cholesterol was found in the simvastatin group than in the untreated group. In summary, apart from lipid lowering among CKD patients, ingesting simvastatin was associated with a decrease in proteinuria. These statin effects may become important for supportive therapy in renal damage in the future. |
| format | Article |
| id | doaj-art-e2f210285ef94571955350aec81ab1e4 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-e2f210285ef94571955350aec81ab1e42025-02-03T01:28:51ZengWileyInternational Journal of Nephrology2090-214X2090-21582015-01-01201510.1155/2015/485839485839The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney DiseaseBancha Satirapoj0Anan Promrattanakun1Ouppatham Supasyndh2Panbuppa Choovichian3Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok 10400, ThailandDivision of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok 10400, ThailandDivision of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok 10400, ThailandDivision of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok 10400, ThailandCurrent data suggests that statins might have beneficial effects on renal outcomes. Beneficial effects of statin treatment on renal progression in advanced chronic kidney disease (CKD) are obviously controversial. In a retrospective, controlled study, the authors have evaluated the effects of 53-week treatment with simvastatin, versus no treatment on proteinuria and renal function among 51 patients with CKD stages III-IV. By the end of the 53-week treatment, urine protein excretion decreased from 0.96 (IQR 0.54, 2.9) to 0.48 (IQR 0.18, 0.79) g/g creatinine (P<0.001) in patients treated with simvastatin in addition to ACEI and ARBs, while no change was observed among the untreated patients. Moreover, a significantly greater decrease in urine protein excretion was observed in the simvastatin group as compared with the untreated group. The mean changes of serum creatinine and eGFR did not significantly differ in both groups. A significantly greater decrease in total cholesterol and LDL-cholesterol was found in the simvastatin group than in the untreated group. In summary, apart from lipid lowering among CKD patients, ingesting simvastatin was associated with a decrease in proteinuria. These statin effects may become important for supportive therapy in renal damage in the future.http://dx.doi.org/10.1155/2015/485839 |
| spellingShingle | Bancha Satirapoj Anan Promrattanakun Ouppatham Supasyndh Panbuppa Choovichian The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease International Journal of Nephrology |
| title | The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease |
| title_full | The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease |
| title_fullStr | The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease |
| title_full_unstemmed | The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease |
| title_short | The Effects of Simvastatin on Proteinuria and Renal Function in Patients with Chronic Kidney Disease |
| title_sort | effects of simvastatin on proteinuria and renal function in patients with chronic kidney disease |
| url | http://dx.doi.org/10.1155/2015/485839 |
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