The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?
One of the main features of the immune response to M. Tuberculosis is the formation of an organized structure called granuloma. It consists mainly in the recruitment at the infectious stage of macrophages, highly differentiated cells such as multinucleated giant cells, epithelioid cells and Foamy ce...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/139127 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548021838020608 |
|---|---|
| author | Mayra Silva Miranda Adrien Breiman Sophie Allain Florence Deknuydt Frederic Altare |
| author_facet | Mayra Silva Miranda Adrien Breiman Sophie Allain Florence Deknuydt Frederic Altare |
| author_sort | Mayra Silva Miranda |
| collection | DOAJ |
| description | One of the main features of the immune response to M. Tuberculosis is the formation of an organized structure called granuloma. It consists mainly in the recruitment at the infectious stage of macrophages, highly differentiated cells such as multinucleated giant cells, epithelioid cells and Foamy cells, all these cells being surrounded by a rim of lymphocytes. Although in the first instance the granuloma acts to constrain the infection, some bacilli can actually survive inside these structures for a long time in a dormant state. For some reasons, which are still unclear, the bacilli will reactivate in 10% of the latently infected individuals, escape the granuloma and spread throughout the body, thus giving rise to clinical disease, and are finally disseminated throughout the environment. In this review we examine the process leading to the formation of the granulomatous structures and the different cell types that have been shown to be part of this inflammatory reaction. We also discuss the different in vivo and in vitro models available to study this fascinating immune structure. |
| format | Article |
| id | doaj-art-e2e271a48b2a44c6a9583e911fad6895 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e2e271a48b2a44c6a9583e911fad68952025-02-03T06:42:27ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/139127139127The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?Mayra Silva Miranda0Adrien Breiman1Sophie Allain2Florence Deknuydt3Frederic Altare4INSERM U892, CNRS UMR 6299, Université de Nantes, 44007 Nantes Cedex 1, FranceINSERM U892, CNRS UMR 6299, Université de Nantes, 44007 Nantes Cedex 1, FranceINSERM U892, CNRS UMR 6299, Université de Nantes, 44007 Nantes Cedex 1, FranceINSERM U892, CNRS UMR 6299, Université de Nantes, 44007 Nantes Cedex 1, FranceINSERM U892, CNRS UMR 6299, Université de Nantes, 44007 Nantes Cedex 1, FranceOne of the main features of the immune response to M. Tuberculosis is the formation of an organized structure called granuloma. It consists mainly in the recruitment at the infectious stage of macrophages, highly differentiated cells such as multinucleated giant cells, epithelioid cells and Foamy cells, all these cells being surrounded by a rim of lymphocytes. Although in the first instance the granuloma acts to constrain the infection, some bacilli can actually survive inside these structures for a long time in a dormant state. For some reasons, which are still unclear, the bacilli will reactivate in 10% of the latently infected individuals, escape the granuloma and spread throughout the body, thus giving rise to clinical disease, and are finally disseminated throughout the environment. In this review we examine the process leading to the formation of the granulomatous structures and the different cell types that have been shown to be part of this inflammatory reaction. We also discuss the different in vivo and in vitro models available to study this fascinating immune structure.http://dx.doi.org/10.1155/2012/139127 |
| spellingShingle | Mayra Silva Miranda Adrien Breiman Sophie Allain Florence Deknuydt Frederic Altare The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria? Clinical and Developmental Immunology |
| title | The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria? |
| title_full | The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria? |
| title_fullStr | The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria? |
| title_full_unstemmed | The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria? |
| title_short | The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria? |
| title_sort | tuberculous granuloma an unsuccessful host defence mechanism providing a safety shelter for the bacteria |
| url | http://dx.doi.org/10.1155/2012/139127 |
| work_keys_str_mv | AT mayrasilvamiranda thetuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria AT adrienbreiman thetuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria AT sophieallain thetuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria AT florencedeknuydt thetuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria AT fredericaltare thetuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria AT mayrasilvamiranda tuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria AT adrienbreiman tuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria AT sophieallain tuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria AT florencedeknuydt tuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria AT fredericaltare tuberculousgranulomaanunsuccessfulhostdefencemechanismprovidingasafetyshelterforthebacteria |