A Mendelian randomization study: physical activities and chronic kidney disease
Increasing evidence has shown that physical activity is related to a lower risk of chronic kidney disease (CKD), thus indicating a potential target for prevention. However, the causality is not clear; specifically, physical activity may protect against CKD, and CKD may lead to a reduction in physica...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2295011 |
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| author | Rui Xiao Li Dong Bo Xie Beizhong Liu |
| author_facet | Rui Xiao Li Dong Bo Xie Beizhong Liu |
| author_sort | Rui Xiao |
| collection | DOAJ |
| description | Increasing evidence has shown that physical activity is related to a lower risk of chronic kidney disease (CKD), thus indicating a potential target for prevention. However, the causality is not clear; specifically, physical activity may protect against CKD, and CKD may lead to a reduction in physical activity. Our study examined the potential bidirectional relationship between physical activity and CKD by using a genetically informed method. Genome-wide association studies from the UK Biobank baseline data were used for physical activity phenotypes and included 460,376 participants. For kidney function (estimated Glomerular Filtration Rate (eGFR) and CKD, with eGFR < 60 mL/min/1.73 m2), CKDGen Consortium data were used, which included 480,698 CKD participants of European ancestry. Mendelian randomization (MR) analysis was used to determine the causal relationship between physical activities and kidney function. Two-sample MR genetically predicted that heavy DIY (do it yourself) (e.g., weeding, lawn mowing, carpentry, and digging) decreased the risk of CKD (odds ratio [OR] = 0.287, 95% CI = 0.117–0.705, p = 0.0065) and improved the level of eGFR (β = 0.036, 95% CI = 0.005–0.067, p = 0.021). The bidirectional MR showed no reverse causality. It is worth noting that other physical activities, such as walking for pleasure, strenuous sports, light DIY (e.g., pruning and watering the lawn), and other exercises (e.g., swimming, cycling, keeping fit, and bowling), were not significantly correlated with CKD and eGFR. This study used genetic data to provide reliable and robust causal evidence that heavy physical activity (e.g., weeding, lawn mowing, carpentry, and digging) can protect kidney function and further lower the risk of CKD. |
| format | Article |
| id | doaj-art-e2dff5b34a9c4faa86c9700043e3358d |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-e2dff5b34a9c4faa86c9700043e3358d2025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2295011A Mendelian randomization study: physical activities and chronic kidney diseaseRui Xiao0Li Dong1Bo Xie2Beizhong Liu3Department of General Practice, Yongchuan Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, ChinaDepartment of Nephrology and Rheumatology, Yongchuan Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, ChinaDepartment of General Practice, Yongchuan Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, ChinaCentral Laboratory of Yongchuan Hospital, Chongqing Medical University, Chongqing, ChinaIncreasing evidence has shown that physical activity is related to a lower risk of chronic kidney disease (CKD), thus indicating a potential target for prevention. However, the causality is not clear; specifically, physical activity may protect against CKD, and CKD may lead to a reduction in physical activity. Our study examined the potential bidirectional relationship between physical activity and CKD by using a genetically informed method. Genome-wide association studies from the UK Biobank baseline data were used for physical activity phenotypes and included 460,376 participants. For kidney function (estimated Glomerular Filtration Rate (eGFR) and CKD, with eGFR < 60 mL/min/1.73 m2), CKDGen Consortium data were used, which included 480,698 CKD participants of European ancestry. Mendelian randomization (MR) analysis was used to determine the causal relationship between physical activities and kidney function. Two-sample MR genetically predicted that heavy DIY (do it yourself) (e.g., weeding, lawn mowing, carpentry, and digging) decreased the risk of CKD (odds ratio [OR] = 0.287, 95% CI = 0.117–0.705, p = 0.0065) and improved the level of eGFR (β = 0.036, 95% CI = 0.005–0.067, p = 0.021). The bidirectional MR showed no reverse causality. It is worth noting that other physical activities, such as walking for pleasure, strenuous sports, light DIY (e.g., pruning and watering the lawn), and other exercises (e.g., swimming, cycling, keeping fit, and bowling), were not significantly correlated with CKD and eGFR. This study used genetic data to provide reliable and robust causal evidence that heavy physical activity (e.g., weeding, lawn mowing, carpentry, and digging) can protect kidney function and further lower the risk of CKD.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2295011Physical activitieschronic kidney diseaseestimated glomerular filtration ratecausal estimatesMendelian randomization |
| spellingShingle | Rui Xiao Li Dong Bo Xie Beizhong Liu A Mendelian randomization study: physical activities and chronic kidney disease Renal Failure Physical activities chronic kidney disease estimated glomerular filtration rate causal estimates Mendelian randomization |
| title | A Mendelian randomization study: physical activities and chronic kidney disease |
| title_full | A Mendelian randomization study: physical activities and chronic kidney disease |
| title_fullStr | A Mendelian randomization study: physical activities and chronic kidney disease |
| title_full_unstemmed | A Mendelian randomization study: physical activities and chronic kidney disease |
| title_short | A Mendelian randomization study: physical activities and chronic kidney disease |
| title_sort | mendelian randomization study physical activities and chronic kidney disease |
| topic | Physical activities chronic kidney disease estimated glomerular filtration rate causal estimates Mendelian randomization |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2295011 |
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