GATA1 activates HSD17B6 to improve efficiency of cisplatin in lung adenocarcinoma via DNA damage

GATA1 activates HSD17B6 to improve efficiency of cisplatin in lung adenocarcinoma via DNA damage

Abstract Background Lung adenocarcinoma (LUAD) is the most common histological type of non-small cell lung cancer (NSCLC). Platinum-based chemotherapy, such as cisplatin chemotherapy, is the cornerstone of treatment for LUAD patients. Nevertheless, cisplatin resistance remains the key obstacle to LU...

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Bibliographic Details
Main Authors: Xingxing Shao, Hailang Hou, Huijie Chen, Wan Xia, Xinpu Geng, Jindao Wang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genes and Environment
Subjects:
GATA1
HSD17B6
DNA damage
Lung adenocarcinoma
Cisplatin resistance
Online Access:https://doi.org/10.1186/s41021-024-00321-9
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https://doi.org/10.1186/s41021-024-00321-9

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