Prevalence and Risk Factors of Hepatitis B and C Virus Co-Infection among Women Attending Antiretroviral Therapy Clinic in Yola, Nigeria
Introduction: Viral hepatitis represents a significant challenge to public health worldwide. Women living with HIV are at heightened risk of coinfection with hepatitis B and C due to their increased risk of exposure to bloodborne pathogens through medical interventions, potentially leading to se...
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| Format: | Article |
| Language: | English |
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Pasteur Institute of Iran
2024-09-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
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| Online Access: | https://jommid.pasteur.ac.ir/article-1-670-en.html |
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| author | Maryam Adam Ibrahim1* James Hamuel Doughari2 |
| author_facet | Maryam Adam Ibrahim1* James Hamuel Doughari2 |
| author_sort | Maryam Adam Ibrahim1* |
| collection | DOAJ |
| description | Introduction: Viral hepatitis represents a significant challenge to public
health worldwide. Women living with HIV are at heightened risk of coinfection
with hepatitis B and C due to their increased risk of exposure to
bloodborne pathogens through medical interventions, potentially leading to
severe health outcomes, including increased morbidity and mortality, and
public health impacts through maternal transmission. This study aimed to
estimate the prevalence of hepatitis B and C virus co-infection among
women living with HIV attending the ART clinic in Modibbo Adama
University Teaching Hospital, Yola, Nigeria. These findings will inform the
development and improvement of testing, vaccination, and treatment
programs to enhance health outcomes and quality of life for this population.
Method: A cross-sectional study was conducted from January 2023 to
September 2023 using a convenience sampling method to recruit 360 women
aged 18 years and above attending the ART clinic. Data on sociodemographic
characteristics and potential risk factors for HBV/HCV
infection were collected with a structured questionnaire. The seroprevalence
of HBsAg and anti-HCV antibodies was determined with Rapid Diagnostic
Test (RDT) strips from Micropoint. Results: Among the 360 HIV-positive
women tested, 9.2% (33) were co-infected with HBV, 2.2% (8) were coinfected
with HCV, and 0.3% (1) had co-infection with HBV, HCV, and
HIV. The prevalence of HBV co-infection was highest among women aged
39-48 (9.6%), while HCV co-infection was most prevalent in those aged 49
and above (3.4%). Logistic regression analysis showed that blood
transfusion and having multiple sexual partners were significantly associated
with HIV/HBV co-infection (P-value = 0.002). Conclusion: This study
identified a notable prevalence of HBV (9.2%) and HCV (2.2%) co-infection
among women living with HIV, underscoring the public health significance
due to the potential for increased morbidity and mortality. Further studies
should employ molecular techniques like PCR to confirm active infections
and assess viral loads. This information is crucial for guiding treatment
decisions and improving clinical outcomes for this vulnerable population. |
| format | Article |
| id | doaj-art-e2dbee0be80c4e8a9924c84dc67cbcf4 |
| institution | OA Journals |
| issn | 2345-5349 2345-5330 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Pasteur Institute of Iran |
| record_format | Article |
| series | Journal of Medical Microbiology and Infectious Diseases |
| spelling | doaj-art-e2dbee0be80c4e8a9924c84dc67cbcf42025-08-20T01:51:06ZengPasteur Institute of IranJournal of Medical Microbiology and Infectious Diseases2345-53492345-53302024-09-0112320821610.61186/JoMMID.12.3.208Prevalence and Risk Factors of Hepatitis B and C Virus Co-Infection among Women Attending Antiretroviral Therapy Clinic in Yola, NigeriaMaryam Adam Ibrahim1*0https://orcid.org/0009-0003-3935-7832James Hamuel Doughari21https://orcid.org/0000-0002-6048-76021College of Nursing and Midwifery, Department of Applied Sciences, PMB 2044, Yola, Nigeria2Modibbo Adama University, Faculty of Life Sciences, Department of Microbiology, PMB 2076, Yola, NigeriaIntroduction: Viral hepatitis represents a significant challenge to public health worldwide. Women living with HIV are at heightened risk of coinfection with hepatitis B and C due to their increased risk of exposure to bloodborne pathogens through medical interventions, potentially leading to severe health outcomes, including increased morbidity and mortality, and public health impacts through maternal transmission. This study aimed to estimate the prevalence of hepatitis B and C virus co-infection among women living with HIV attending the ART clinic in Modibbo Adama University Teaching Hospital, Yola, Nigeria. These findings will inform the development and improvement of testing, vaccination, and treatment programs to enhance health outcomes and quality of life for this population. Method: A cross-sectional study was conducted from January 2023 to September 2023 using a convenience sampling method to recruit 360 women aged 18 years and above attending the ART clinic. Data on sociodemographic characteristics and potential risk factors for HBV/HCV infection were collected with a structured questionnaire. The seroprevalence of HBsAg and anti-HCV antibodies was determined with Rapid Diagnostic Test (RDT) strips from Micropoint. Results: Among the 360 HIV-positive women tested, 9.2% (33) were co-infected with HBV, 2.2% (8) were coinfected with HCV, and 0.3% (1) had co-infection with HBV, HCV, and HIV. The prevalence of HBV co-infection was highest among women aged 39-48 (9.6%), while HCV co-infection was most prevalent in those aged 49 and above (3.4%). Logistic regression analysis showed that blood transfusion and having multiple sexual partners were significantly associated with HIV/HBV co-infection (P-value = 0.002). Conclusion: This study identified a notable prevalence of HBV (9.2%) and HCV (2.2%) co-infection among women living with HIV, underscoring the public health significance due to the potential for increased morbidity and mortality. Further studies should employ molecular techniques like PCR to confirm active infections and assess viral loads. This information is crucial for guiding treatment decisions and improving clinical outcomes for this vulnerable population.https://jommid.pasteur.ac.ir/article-1-670-en.htmlco-infectionhepatitis b virushepatitis c virushiv infectionnigeriarisk factorswomen living with hiv |
| spellingShingle | Maryam Adam Ibrahim1* James Hamuel Doughari2 Prevalence and Risk Factors of Hepatitis B and C Virus Co-Infection among Women Attending Antiretroviral Therapy Clinic in Yola, Nigeria Journal of Medical Microbiology and Infectious Diseases co-infection hepatitis b virus hepatitis c virus hiv infection nigeria risk factors women living with hiv |
| title | Prevalence and Risk Factors of Hepatitis B and C Virus Co-Infection among Women Attending Antiretroviral Therapy Clinic in Yola, Nigeria |
| title_full | Prevalence and Risk Factors of Hepatitis B and C Virus Co-Infection among Women Attending Antiretroviral Therapy Clinic in Yola, Nigeria |
| title_fullStr | Prevalence and Risk Factors of Hepatitis B and C Virus Co-Infection among Women Attending Antiretroviral Therapy Clinic in Yola, Nigeria |
| title_full_unstemmed | Prevalence and Risk Factors of Hepatitis B and C Virus Co-Infection among Women Attending Antiretroviral Therapy Clinic in Yola, Nigeria |
| title_short | Prevalence and Risk Factors of Hepatitis B and C Virus Co-Infection among Women Attending Antiretroviral Therapy Clinic in Yola, Nigeria |
| title_sort | prevalence and risk factors of hepatitis b and c virus co infection among women attending antiretroviral therapy clinic in yola nigeria |
| topic | co-infection hepatitis b virus hepatitis c virus hiv infection nigeria risk factors women living with hiv |
| url | https://jommid.pasteur.ac.ir/article-1-670-en.html |
| work_keys_str_mv | AT maryamadamibrahim1 prevalenceandriskfactorsofhepatitisbandcviruscoinfectionamongwomenattendingantiretroviraltherapyclinicinyolanigeria AT jameshamueldoughari2 prevalenceandriskfactorsofhepatitisbandcviruscoinfectionamongwomenattendingantiretroviraltherapyclinicinyolanigeria |