Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)
5-Aminolevulinic acid (5-ALA) is a delta amino acid naturally present in every living cell of the human body. 5-ALA is produced in the mitochondria as the first product of the porphyrin synthesis pathway and composes heme; exogenously supplemented 5-ALA helps in upregulating mitochondrial functions....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/4267357 |
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| _version_ | 1832554324884979712 |
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| author | Peter R. Rehani Hanaa Iftikhar Motowo Nakajima Tohru Tanaka Zaid Jabbar Riyadh N. Rehani |
| author_facet | Peter R. Rehani Hanaa Iftikhar Motowo Nakajima Tohru Tanaka Zaid Jabbar Riyadh N. Rehani |
| author_sort | Peter R. Rehani |
| collection | DOAJ |
| description | 5-Aminolevulinic acid (5-ALA) is a delta amino acid naturally present in every living cell of the human body. 5-ALA is produced in the mitochondria as the first product of the porphyrin synthesis pathway and composes heme; exogenously supplemented 5-ALA helps in upregulating mitochondrial functions. Mitochondrial dysfunction has been associated with the pathophysiology of diabetes mellitus. Thus, in this review, we evaluate the mechanisms of action and adverse effects of common medications used to treat type 2 diabetes mellitus as well as 5-ALA including its mechanism and possible use in diabetes management. |
| format | Article |
| id | doaj-art-e2d8aca655fe4c7db928f82d203b2f38 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e2d8aca655fe4c7db928f82d203b2f382025-02-03T05:51:50ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/42673574267357Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)Peter R. Rehani0Hanaa Iftikhar1Motowo Nakajima2Tohru Tanaka3Zaid Jabbar4Riyadh N. Rehani5University of Wisconsin-Madison, Madison WI, USARoyal College of Surgeons in Ireland, BahrainSBI Pharmaceuticals Co. Ltd., Tokyo, JapanSBI Pharmaceuticals Co. Ltd., Tokyo, JapanDuPage Medical Group, Chicago, IL, USASBI ALApharma Co. Ltd., Hong Kong5-Aminolevulinic acid (5-ALA) is a delta amino acid naturally present in every living cell of the human body. 5-ALA is produced in the mitochondria as the first product of the porphyrin synthesis pathway and composes heme; exogenously supplemented 5-ALA helps in upregulating mitochondrial functions. Mitochondrial dysfunction has been associated with the pathophysiology of diabetes mellitus. Thus, in this review, we evaluate the mechanisms of action and adverse effects of common medications used to treat type 2 diabetes mellitus as well as 5-ALA including its mechanism and possible use in diabetes management.http://dx.doi.org/10.1155/2019/4267357 |
| spellingShingle | Peter R. Rehani Hanaa Iftikhar Motowo Nakajima Tohru Tanaka Zaid Jabbar Riyadh N. Rehani Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA) Journal of Diabetes Research |
| title | Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA) |
| title_full | Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA) |
| title_fullStr | Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA) |
| title_full_unstemmed | Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA) |
| title_short | Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA) |
| title_sort | safety and mode of action of diabetes medications in comparison with 5 aminolevulinic acid 5 ala |
| url | http://dx.doi.org/10.1155/2019/4267357 |
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