Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum)
Noscapine, a phthalideisoquinoline alkaloid derived from opium, has been used in the treatment of various cancer types. Its low-toxicity profile has increased attention to this alkaloid. With regard to increasing demand for this compound, we developed a new method for isolation of noscapine from dri...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/493870 |
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| author | Ibrahim Bulduk Fulya Taktak |
| author_facet | Ibrahim Bulduk Fulya Taktak |
| author_sort | Ibrahim Bulduk |
| collection | DOAJ |
| description | Noscapine, a phthalideisoquinoline alkaloid derived from opium, has been used in the treatment of various cancer types. Its low-toxicity profile has increased attention to this alkaloid. With regard to increasing demand for this compound, we developed a new method for isolation of noscapine from dried capsules of Papaver somniferum. Noscapine was successfully isolated from poppy capsules for the first time and the purity of the isolated compound was determined to be over 99.59% by HPLC analysis. The structure of noscapine was confirmed by 1H NMR, 13C NMR, FT-IR, elemental analysis, and HR-ESI-MS methods. |
| format | Article |
| id | doaj-art-e2d6f60d429b4c119feca1a2814004e7 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e2d6f60d429b4c119feca1a2814004e72025-02-03T06:06:36ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/493870493870Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum)Ibrahim Bulduk0Fulya Taktak1Department of Chemistry, University of Uşak, 64200 Uşak, TurkeyDepartment of Chemical Engineering, University of Uşak, 64200 Uşak, TurkeyNoscapine, a phthalideisoquinoline alkaloid derived from opium, has been used in the treatment of various cancer types. Its low-toxicity profile has increased attention to this alkaloid. With regard to increasing demand for this compound, we developed a new method for isolation of noscapine from dried capsules of Papaver somniferum. Noscapine was successfully isolated from poppy capsules for the first time and the purity of the isolated compound was determined to be over 99.59% by HPLC analysis. The structure of noscapine was confirmed by 1H NMR, 13C NMR, FT-IR, elemental analysis, and HR-ESI-MS methods.http://dx.doi.org/10.1155/2013/493870 |
| spellingShingle | Ibrahim Bulduk Fulya Taktak Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum) Journal of Chemistry |
| title | Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum) |
| title_full | Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum) |
| title_fullStr | Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum) |
| title_full_unstemmed | Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum) |
| title_short | Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum) |
| title_sort | isolation and characterization of antitumor alkaloid from poppy capsules papaver somniferum |
| url | http://dx.doi.org/10.1155/2013/493870 |
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