Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism
Aim. Ventilation with pure oxygen (hyperoxic ventilation: HV) is thought to decrease whole body oxygen consumption (VO2). However, the validity and impact of this phenomenon remain ambiguous; until now, under hyperoxic conditions, VO2 has only been determined by the reverse Fick principle, a method...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/410321 |
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| author | Patrick Lauscher Sabine Lauscher Harry Kertscho Oliver Habler Jens Meier |
| author_facet | Patrick Lauscher Sabine Lauscher Harry Kertscho Oliver Habler Jens Meier |
| author_sort | Patrick Lauscher |
| collection | DOAJ |
| description | Aim. Ventilation with pure oxygen (hyperoxic ventilation: HV) is thought to decrease whole body oxygen consumption (VO2). However, the validity and impact of this phenomenon remain ambiguous; until now, under hyperoxic conditions, VO2 has only been determined by the reverse Fick principle, a method with inherent methodological problems. The goal of this study was to determine changes of VO2, carbon dioxide production (VCO2), and the respiratory quotient (RQ) during normoxic and hyperoxic ventilation, using a metabolic monitor.
Methods. After providing signed informed consent and institutional acceptance, 14 healthy volunteers were asked to sequentially breathe room air, pure oxygen, and room air again. VO2, VCO2, RQ, and energy expenditure (EE) were determined by indirect calorimetry using a modified metabolic monitor during HV. Results. HV reduced VO2 from 3.4 (3.0/4.0) mL/kg/min to 2.8 (2.5/3.6) mL/kg/min (P<0.05), whereas VCO2 remained constant (3.0 [2.6/3.6] mL/kg/min versus 3.0 [2.6/3.5] mL/kg/min, n.s.). After onset of HV, RQ increased from 0.9 (0.8/0.9) to 1.1 (1.0/1.1). Most changes during HV were immediately reversed during subsequent normoxic ventilation.
Conclusion. HV not only reduces VO2, but also increases the respiratory quotient. This might be interpreted as an indicator of the substantial metabolic changes induced by HV. However, the impact of this phenomenon requires further study. |
| format | Article |
| id | doaj-art-e2d60276725b42b2b85f8f04efdf156e |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | The Scientific World Journal |
| spelling | doaj-art-e2d60276725b42b2b85f8f04efdf156e2025-02-03T06:01:18ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/410321410321Hyperoxia Reversibly Alters Oxygen Consumption and MetabolismPatrick Lauscher0Sabine Lauscher1Harry Kertscho2Oliver Habler3Jens Meier4Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Eberhard-Karls University, 72076 Tübingen, GermanyClinic of Anesthesiology, Intensive Care Medicine, and Pain Control, Nord-West Hospital, 60488 Frankfurt, GermanyClinic of Anesthesiology, Intensive Care Medicine and Pain, Therapy Goethe-University Hospital Center, 60590 Frankfurt, GermanyClinic of Anesthesiology, Intensive Care Medicine, and Pain Control, Nord-West Hospital, 60488 Frankfurt, GermanyDepartment of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Eberhard-Karls University, 72076 Tübingen, GermanyAim. Ventilation with pure oxygen (hyperoxic ventilation: HV) is thought to decrease whole body oxygen consumption (VO2). However, the validity and impact of this phenomenon remain ambiguous; until now, under hyperoxic conditions, VO2 has only been determined by the reverse Fick principle, a method with inherent methodological problems. The goal of this study was to determine changes of VO2, carbon dioxide production (VCO2), and the respiratory quotient (RQ) during normoxic and hyperoxic ventilation, using a metabolic monitor. Methods. After providing signed informed consent and institutional acceptance, 14 healthy volunteers were asked to sequentially breathe room air, pure oxygen, and room air again. VO2, VCO2, RQ, and energy expenditure (EE) were determined by indirect calorimetry using a modified metabolic monitor during HV. Results. HV reduced VO2 from 3.4 (3.0/4.0) mL/kg/min to 2.8 (2.5/3.6) mL/kg/min (P<0.05), whereas VCO2 remained constant (3.0 [2.6/3.6] mL/kg/min versus 3.0 [2.6/3.5] mL/kg/min, n.s.). After onset of HV, RQ increased from 0.9 (0.8/0.9) to 1.1 (1.0/1.1). Most changes during HV were immediately reversed during subsequent normoxic ventilation. Conclusion. HV not only reduces VO2, but also increases the respiratory quotient. This might be interpreted as an indicator of the substantial metabolic changes induced by HV. However, the impact of this phenomenon requires further study.http://dx.doi.org/10.1100/2012/410321 |
| spellingShingle | Patrick Lauscher Sabine Lauscher Harry Kertscho Oliver Habler Jens Meier Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism The Scientific World Journal |
| title | Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism |
| title_full | Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism |
| title_fullStr | Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism |
| title_full_unstemmed | Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism |
| title_short | Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism |
| title_sort | hyperoxia reversibly alters oxygen consumption and metabolism |
| url | http://dx.doi.org/10.1100/2012/410321 |
| work_keys_str_mv | AT patricklauscher hyperoxiareversiblyaltersoxygenconsumptionandmetabolism AT sabinelauscher hyperoxiareversiblyaltersoxygenconsumptionandmetabolism AT harrykertscho hyperoxiareversiblyaltersoxygenconsumptionandmetabolism AT oliverhabler hyperoxiareversiblyaltersoxygenconsumptionandmetabolism AT jensmeier hyperoxiareversiblyaltersoxygenconsumptionandmetabolism |