Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry
ABSTRACT The analysis of intrathecal IgG, IgA and IgM synthesis in cerebrospinal fluid (CSF) and evaluation in combined quotient diagrams provides disease-related patterns. The compilation with complementary parameters (barrier function, i.e., CSF flow rate, cytology, lactate, antibodies) in a cumul...
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| Language: | English |
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Thieme Revinter Publicações
2016-04-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000400012&lng=en&tlng=en |
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| _version_ | 1849691221382922240 |
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| author | Hansotto Reiber |
| author_facet | Hansotto Reiber |
| author_sort | Hansotto Reiber |
| collection | DOAJ |
| description | ABSTRACT The analysis of intrathecal IgG, IgA and IgM synthesis in cerebrospinal fluid (CSF) and evaluation in combined quotient diagrams provides disease-related patterns. The compilation with complementary parameters (barrier function, i.e., CSF flow rate, cytology, lactate, antibodies) in a cumulative CSF data report allows a knowledge-based interpretation and provides analytical and medical plausibility for the quality assessment in CSF laboratories. The diagnostic relevance is described for neurological and psychiatric diseases, for which CSF analysis can’t be replaced by other diagnostic methods without loss of information. Dominance of intrathecal IgM, IgA or three class immune responses give a systematic approach for Facial nerve palsy, Neurotrypanosomiasis, Opportunistic diseases, lymphoma, Neurotuberculosis, Adrenoleucodystrophy or tumor metastases. Particular applications consider the diagnostic power of the polyspecific antibody response (MRZ-antibodies) in multiple sclerosis, a CSF-related systematic view on differential diagnostic of psychiatric diseases and the dynamics of brain- derived compared to blood-derived molecules in CSF for localization of paracytes. |
| format | Article |
| id | doaj-art-e2d5fc80459d4e5c9ed9f0a2745552b3 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2016-04-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-e2d5fc80459d4e5c9ed9f0a2745552b32025-08-20T03:21:06ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272016-04-0174433735010.1590/0004-282X20160044S0004-282X2016000400012Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatryHansotto ReiberABSTRACT The analysis of intrathecal IgG, IgA and IgM synthesis in cerebrospinal fluid (CSF) and evaluation in combined quotient diagrams provides disease-related patterns. The compilation with complementary parameters (barrier function, i.e., CSF flow rate, cytology, lactate, antibodies) in a cumulative CSF data report allows a knowledge-based interpretation and provides analytical and medical plausibility for the quality assessment in CSF laboratories. The diagnostic relevance is described for neurological and psychiatric diseases, for which CSF analysis can’t be replaced by other diagnostic methods without loss of information. Dominance of intrathecal IgM, IgA or three class immune responses give a systematic approach for Facial nerve palsy, Neurotrypanosomiasis, Opportunistic diseases, lymphoma, Neurotuberculosis, Adrenoleucodystrophy or tumor metastases. Particular applications consider the diagnostic power of the polyspecific antibody response (MRZ-antibodies) in multiple sclerosis, a CSF-related systematic view on differential diagnostic of psychiatric diseases and the dynamics of brain- derived compared to blood-derived molecules in CSF for localization of paracytes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000400012&lng=en&tlng=enliquido cefalorraquidianoimunoglobulinasanticorposdoenças do sistema nervosodoenças neurológicasficha clínica |
| spellingShingle | Hansotto Reiber Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry Arquivos de Neuro-Psiquiatria liquido cefalorraquidiano imunoglobulinas anticorpos doenças do sistema nervoso doenças neurológicas ficha clínica |
| title | Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry |
| title_full | Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry |
| title_fullStr | Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry |
| title_full_unstemmed | Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry |
| title_short | Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry |
| title_sort | cerebrospinal fluid data compilation and knowledge based interpretation of bacterial viral parasitic oncological chronic inflammatory and demyelinating diseases diagnostic patterns not to be missed in neurology and psychiatry |
| topic | liquido cefalorraquidiano imunoglobulinas anticorpos doenças do sistema nervoso doenças neurológicas ficha clínica |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000400012&lng=en&tlng=en |
| work_keys_str_mv | AT hansottoreiber cerebrospinalfluiddatacompilationandknowledgebasedinterpretationofbacterialviralparasiticoncologicalchronicinflammatoryanddemyelinatingdiseasesdiagnosticpatternsnottobemissedinneurologyandpsychiatry |