Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment

Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment

BackgroundInsulin resistance is tightly related to cognition; however, the causal association between them remains a matter of debate. Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brai...

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Bibliographic Details
Main Authors: Chaojuan Huang, Yuyang Zhang, Mingxu Li, Qiuju Gong, Siqi Yu, Zhiwei Li, Mengmeng Ren, Xia Zhou, Xiaoqun Zhu, Zhongwu Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Endocrinology
Subjects:
brain cortical structure
cognition
insulin resistance
mediation
Mendelian randomization
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1443301/full
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