Tumor microenvironment remodeling with a telomere-targeting agent and its cooperative antitumor effects with a nanovaccine

Tumor microenvironment remodeling with a telomere-targeting agent and its cooperative antitumor effects with a nanovaccine

Abstract The nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG, also known as THIO) is a telomere-targeting agent with important clinical potency. It can selectively kill telomerase-positive tumor cells. We previously reported that THIO could successfully induce immunogenic cell death (IC...

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Main Authors: Jing Bai, Mengzhen Wang, Yiming Luo, Biao Duan, Ying Yang, Yuting Fu, Shuqin Li, Zhongqian Yang, Peng Zheng, Tong Yu, Xin Yin, Hongmei Bai, Qiong Long, Yanbing Ma
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
6-thio-2′-deoxyguanosine (THIO)
Immunogenic cell death (ICD)
Tumor immunotherapy
Cancer vaccine
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12951-025-03471-2
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https://doi.org/10.1186/s12951-025-03471-2

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