The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium
Schistosomes are long-lived parasites, hence schistosomiasis is a chronic disease with severe long-term implications. However, definitive diagnosis of active infection has been difficult because demonstration of infection has depended on detecting parasite eggs in urine and/or stool. In the case of...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2012/761269 |
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| author | Clive Shiff |
| author_facet | Clive Shiff |
| author_sort | Clive Shiff |
| collection | DOAJ |
| description | Schistosomes are long-lived parasites, hence schistosomiasis is a chronic disease with severe long-term implications. However, definitive diagnosis of active infection has been difficult because demonstration of infection has depended on detecting parasite eggs in urine and/or stool. In the case of Schistosoma haematobium which parasitizes the urinogenital system, this method has low sensitivity in adults. Detection of parasite-specific DNA in urine has been demonstrated and this has similar specificity but improved sensitivity. The implications of this new procedure and the impact on diagnosis are discussed. |
| format | Article |
| id | doaj-art-e2c7121648264deea64ccb82684ec214 |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-e2c7121648264deea64ccb82684ec2142025-02-03T07:23:32ZengWileyJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/761269761269The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobiumClive Shiff0Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USASchistosomes are long-lived parasites, hence schistosomiasis is a chronic disease with severe long-term implications. However, definitive diagnosis of active infection has been difficult because demonstration of infection has depended on detecting parasite eggs in urine and/or stool. In the case of Schistosoma haematobium which parasitizes the urinogenital system, this method has low sensitivity in adults. Detection of parasite-specific DNA in urine has been demonstrated and this has similar specificity but improved sensitivity. The implications of this new procedure and the impact on diagnosis are discussed.http://dx.doi.org/10.1155/2012/761269 |
| spellingShingle | Clive Shiff The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium Journal of Parasitology Research |
| title | The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium |
| title_full | The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium |
| title_fullStr | The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium |
| title_full_unstemmed | The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium |
| title_short | The Importance of Definitive Diagnosis in Chronic Schistosomiasis, with Reference to Schistosoma haematobium |
| title_sort | importance of definitive diagnosis in chronic schistosomiasis with reference to schistosoma haematobium |
| url | http://dx.doi.org/10.1155/2012/761269 |
| work_keys_str_mv | AT cliveshiff theimportanceofdefinitivediagnosisinchronicschistosomiasiswithreferencetoschistosomahaematobium AT cliveshiff importanceofdefinitivediagnosisinchronicschistosomiasiswithreferencetoschistosomahaematobium |