Methionine restriction promotes the polarization of macrophages towards M1 and the immunotherapy effect of PD-L1/PD-1 blockades by inhibiting the secretion of MIF by gastric carcinoma cells

Methionine restriction promotes the polarization of macrophages towards M1 and the immunotherapy effect of PD-L1/PD-1 blockades by inhibiting the secretion of MIF by gastric carcinoma cells

Background: The limited curative effect of PD-L1/PD-1 blockades presents challenges to immunotherapy for advanced gastric cancer. We have found that methionine restriction (MR) enhances the drug resistance of gastric carcinoma cells. We aimed to explore whether MR can enhance the efficacy of PD-L1/P...

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Bibliographic Details
Main Authors: Lin Xin, Jiang Liu, Jun-Yan Lai, He-Song Xu, Luo-Jun Fan, Yong-Hui Zou, Qi Zhou, Zhen- Qi Yue, Jin-Heng Gan
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Translational Oncology
Subjects:
Methionine restriction
MIF
Gastric cancer
PD-L1/PD-1 blocker
Macrophage polarization
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523324003073
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