DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a perplexing and potentially severe disease, the pathogenesis of which is yet to be understood. SLE is considered to be a multifactorial disease, in which genetic factors, immune dysregulation, and environmental factors, such as ultraviolet radiation, are involv...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8214379 |
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| author | Martha Paola Mireles-Canales Susana Aideé González-Chávez Celia Maria Quiñonez-Flores Ever Adán León-López César Pacheco-Tena |
| author_facet | Martha Paola Mireles-Canales Susana Aideé González-Chávez Celia Maria Quiñonez-Flores Ever Adán León-López César Pacheco-Tena |
| author_sort | Martha Paola Mireles-Canales |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a perplexing and potentially severe disease, the pathogenesis of which is yet to be understood. SLE is considered to be a multifactorial disease, in which genetic factors, immune dysregulation, and environmental factors, such as ultraviolet radiation, are involved. Recently, the description of novel genes conferring susceptibility to develop SLE even in their own (monogenic lupus) has raised the interest in DNA dynamics since many of these genes are linked to DNA repair. Damage to DNA induces an inflammatory response and eventually triggers an immune response, including those targeting self-antigens. We review the evidence that indicates that patients with SLE present higher levels of DNA damage than normal subjects do and that several proteins involved in the preservation of the genomic stability show polymorphisms, some of which increase the risk for SLE development. Also, the experience from animal models reinforces the connection between DNA damage and defective repair in the development of SLE-like disease including characteristic features such as anti-DNA antibodies and nephritis. Defining the role of DNA damage response in SLE pathogenesis might be strategic in the quest for novel therapies. |
| format | Article |
| id | doaj-art-e2bd037f06da4ae288574076b2172b21 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e2bd037f06da4ae288574076b2172b212025-08-20T02:21:14ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/82143798214379DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus ErythematosusMartha Paola Mireles-Canales0Susana Aideé González-Chávez1Celia Maria Quiñonez-Flores2Ever Adán León-López3César Pacheco-Tena4Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua, CHIH, MexicoFacultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua, CHIH, MexicoFacultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua, CHIH, MexicoFacultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua, CHIH, MexicoFacultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua, CHIH, MexicoSystemic lupus erythematosus (SLE) is a perplexing and potentially severe disease, the pathogenesis of which is yet to be understood. SLE is considered to be a multifactorial disease, in which genetic factors, immune dysregulation, and environmental factors, such as ultraviolet radiation, are involved. Recently, the description of novel genes conferring susceptibility to develop SLE even in their own (monogenic lupus) has raised the interest in DNA dynamics since many of these genes are linked to DNA repair. Damage to DNA induces an inflammatory response and eventually triggers an immune response, including those targeting self-antigens. We review the evidence that indicates that patients with SLE present higher levels of DNA damage than normal subjects do and that several proteins involved in the preservation of the genomic stability show polymorphisms, some of which increase the risk for SLE development. Also, the experience from animal models reinforces the connection between DNA damage and defective repair in the development of SLE-like disease including characteristic features such as anti-DNA antibodies and nephritis. Defining the role of DNA damage response in SLE pathogenesis might be strategic in the quest for novel therapies.http://dx.doi.org/10.1155/2018/8214379 |
| spellingShingle | Martha Paola Mireles-Canales Susana Aideé González-Chávez Celia Maria Quiñonez-Flores Ever Adán León-López César Pacheco-Tena DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus Journal of Immunology Research |
| title | DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus |
| title_full | DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus |
| title_fullStr | DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus |
| title_full_unstemmed | DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus |
| title_short | DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus |
| title_sort | dna damage and deficiencies in the mechanisms of its repair implications in the pathogenesis of systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2018/8214379 |
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