Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer
Background. T393C polymorphism in the gene GNAS1, which encodes the G-protein alpha s subunit (Gαs) of heterotrimeric G protein, is significantly associated with the clinical outcome of patients suffering from several cancers. However, studies on the role and protein expression of Gαs subunit in pro...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/301376 |
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| author | Lijuan Wang Guihua Jin Chenchen He Xijing Guo Xia Zhou Meng Li Xia Ying Le Wang Huili Wu Qing Zhu |
| author_facet | Lijuan Wang Guihua Jin Chenchen He Xijing Guo Xia Zhou Meng Li Xia Ying Le Wang Huili Wu Qing Zhu |
| author_sort | Lijuan Wang |
| collection | DOAJ |
| description | Background. T393C polymorphism in the gene GNAS1, which encodes the G-protein alpha s subunit (Gαs) of heterotrimeric G protein, is significantly associated with the clinical outcome of patients suffering from several cancers. However, studies on the role and protein expression of Gαs subunit in prostate cancer were still unavailable. Methods. The immunohistochemical staining was used to assess Gαs expression through tissue microarray procedure of 56 metastatic PCas, 291 localized PCas, and 67 benign hyperplasia (BPH). Gαs expression was semiquantitatively scored and evaluated the correlation with pathologic parameters and biochemical recurrence of prostate-specific antigen (PSA). Results. Gαs expression was localized in nuclear and cytoplasm in prostate cancer cells and downregulated in metastatic PCa compared to localized PCa and BPH (P<0.001). Gαs was inversely associated with PSA level and Gleason scores; patients with low expression of Gαs had adverse clincopathological features. In multivariable Cox regression analysis, high Gαs expression and Gleason scores were independent predictors of both PSA progression-free and overall survival. Conclusions. Gαs down-expression is associated with adverse pathologic features and clinical PSA biochemical recurrence of prostate cancer. Gαs is an independent predictor to help determine the risk of PSA progression and death. |
| format | Article |
| id | doaj-art-e2b861a61c234393bc7dc44ca4693778 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e2b861a61c234393bc7dc44ca46937782025-02-03T01:08:50ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/301376301376Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate CancerLijuan Wang0Guihua Jin1Chenchen He2Xijing Guo3Xia Zhou4Meng Li5Xia Ying6Le Wang7Huili Wu8Qing Zhu9Department of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaDepartment of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, ChinaBackground. T393C polymorphism in the gene GNAS1, which encodes the G-protein alpha s subunit (Gαs) of heterotrimeric G protein, is significantly associated with the clinical outcome of patients suffering from several cancers. However, studies on the role and protein expression of Gαs subunit in prostate cancer were still unavailable. Methods. The immunohistochemical staining was used to assess Gαs expression through tissue microarray procedure of 56 metastatic PCas, 291 localized PCas, and 67 benign hyperplasia (BPH). Gαs expression was semiquantitatively scored and evaluated the correlation with pathologic parameters and biochemical recurrence of prostate-specific antigen (PSA). Results. Gαs expression was localized in nuclear and cytoplasm in prostate cancer cells and downregulated in metastatic PCa compared to localized PCa and BPH (P<0.001). Gαs was inversely associated with PSA level and Gleason scores; patients with low expression of Gαs had adverse clincopathological features. In multivariable Cox regression analysis, high Gαs expression and Gleason scores were independent predictors of both PSA progression-free and overall survival. Conclusions. Gαs down-expression is associated with adverse pathologic features and clinical PSA biochemical recurrence of prostate cancer. Gαs is an independent predictor to help determine the risk of PSA progression and death.http://dx.doi.org/10.1155/2014/301376 |
| spellingShingle | Lijuan Wang Guihua Jin Chenchen He Xijing Guo Xia Zhou Meng Li Xia Ying Le Wang Huili Wu Qing Zhu Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer Journal of Immunology Research |
| title | Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer |
| title_full | Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer |
| title_fullStr | Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer |
| title_full_unstemmed | Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer |
| title_short | Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer |
| title_sort | gαs protein expression is an independent predictor of recurrence in prostate cancer |
| url | http://dx.doi.org/10.1155/2014/301376 |
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