Uptake of fucosylated type I human milk oligosaccharide blocks by Bifidobacterium longum subsp. infantis

Uptake of fucosylated type I human milk oligosaccharide blocks by Bifidobacterium longum subsp. infantis

ABSTRACT Human milk oligosaccharides (HMOs) are uniquely rich in the type 1 building block disaccharide lacto-N-biose I (LNB; Galβ1,3GlcNAc), as compared to other mammals. Most HMOs are fucosylated, for example, α1,2 and α1,4 fucosylations on LNB blocks, resulting in H type 1 (H1) and Lewis a (Lea)...

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Main Authors: Morten Ejby Hansen, Mikiyasu Sakanaka, Mathias Jensen, Hiroka Sakanaka, Michael Jakob Pichler, Shingo Maeda, Julie Franck Høvring, Aruto Nakajima, Sonja Kunstmann, Tine Sofie Nielsen, Günther Herbert Johannes Peters, Dirk Jan Slotboom, Jens Preben Morth, Takane Katayama, Maher Abou Hachem
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
ABC transporter
Bifidobacterium
human gut microbiota
human milk oligosaccharides
mother's milk
Online Access:https://journals.asm.org/doi/10.1128/mbio.00368-25
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