Identification of Bioactive Substances Derived from the Probiotic-Induced Bioconversion of <i>Lagerstroemia speciosa</i> Pers. Leaf Extract That Have Beneficial Effects on Diabetes and Obesity
<i>Lagerstroemia speciosa</i> L. (Banaba) has been used as a functional food because of its diuretic, decongestant, antipyretic, anti-hyperglycemic, and anti-adipogenic activities. Triterpene acids, including corosolic acid, oleanolic acid, and asiatic acid, are the principal phytochemic...
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2024-09-01
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| author | Byung Chull An Sang Hee Kwak Jun Young Ahn Hye Yeon Won Tae Hoon Kim Yongku Ryu Myung Jun Chung |
| author_facet | Byung Chull An Sang Hee Kwak Jun Young Ahn Hye Yeon Won Tae Hoon Kim Yongku Ryu Myung Jun Chung |
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| description | <i>Lagerstroemia speciosa</i> L. (Banaba) has been used as a functional food because of its diuretic, decongestant, antipyretic, anti-hyperglycemic, and anti-adipogenic activities. Triterpene acids, including corosolic acid, oleanolic acid, and asiatic acid, are the principal phytochemicals in Banaba and are potentially anti-diabetic substances, owing to their effect on blood glucose concentration. Bioconversion of Banaba leaf extract (BLE) by <i>Lactobacillus plantarum</i> CBT-LP3 improved the glucose uptake, insulin secretion, and fat browning of this functional food. Furthermore, we identified asiatic acid, which was found to be increased by 3.8-fold during the <i>L. plantarum</i> CBT-LP3-mediated bioconversion process using metabolite profiling. Most previous studies have focused on corosolic acid, another triterpene acid that is a known anti-diabetic compound and is used to standardize BLE preparations. However, asiatic acid is the second most common of the triterpene acids and is also well known to have anti-diabetic properties. The present study has provided strong evidence that asiatic acid represents an alternative to corosolic acid as the most important active compound. These results suggest that the probiotic-mediated bioconversion of BLE may improve the anti-diabetic effects of this functional food. This implies that the consumption of a probiotic should be encouraged for people undergoing BLE treatment to improve its anti-diabetic effects. |
| format | Article |
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| spelling | doaj-art-e2b64490cecb477ebb16ebc47655fb492025-08-20T01:55:41ZengMDPI AGMicroorganisms2076-26072024-09-01129184810.3390/microorganisms12091848Identification of Bioactive Substances Derived from the Probiotic-Induced Bioconversion of <i>Lagerstroemia speciosa</i> Pers. Leaf Extract That Have Beneficial Effects on Diabetes and ObesityByung Chull An0Sang Hee Kwak1Jun Young Ahn2Hye Yeon Won3Tae Hoon Kim4Yongku Ryu5Myung Jun Chung6R&D Center, Cell Biotech Co., Ltd., Gimpo-si 10003, Republic of KoreaR&D Center, Cell Biotech Co., Ltd., Gimpo-si 10003, Republic of KoreaR&D Center, Cell Biotech Co., Ltd., Gimpo-si 10003, Republic of KoreaR&D Center, Cell Biotech Co., Ltd., Gimpo-si 10003, Republic of KoreaDepartment of Food Science and Biotechnology, Daegu University, Gyeongsan 38453, Republic of KoreaR&D Center, Cell Biotech Co., Ltd., Gimpo-si 10003, Republic of KoreaR&D Center, Cell Biotech Co., Ltd., Gimpo-si 10003, Republic of Korea<i>Lagerstroemia speciosa</i> L. (Banaba) has been used as a functional food because of its diuretic, decongestant, antipyretic, anti-hyperglycemic, and anti-adipogenic activities. Triterpene acids, including corosolic acid, oleanolic acid, and asiatic acid, are the principal phytochemicals in Banaba and are potentially anti-diabetic substances, owing to their effect on blood glucose concentration. Bioconversion of Banaba leaf extract (BLE) by <i>Lactobacillus plantarum</i> CBT-LP3 improved the glucose uptake, insulin secretion, and fat browning of this functional food. Furthermore, we identified asiatic acid, which was found to be increased by 3.8-fold during the <i>L. plantarum</i> CBT-LP3-mediated bioconversion process using metabolite profiling. Most previous studies have focused on corosolic acid, another triterpene acid that is a known anti-diabetic compound and is used to standardize BLE preparations. However, asiatic acid is the second most common of the triterpene acids and is also well known to have anti-diabetic properties. The present study has provided strong evidence that asiatic acid represents an alternative to corosolic acid as the most important active compound. These results suggest that the probiotic-mediated bioconversion of BLE may improve the anti-diabetic effects of this functional food. This implies that the consumption of a probiotic should be encouraged for people undergoing BLE treatment to improve its anti-diabetic effects.https://www.mdpi.com/2076-2607/12/9/1848<i>Lactobacillus plantarum</i> CBT-LP3probioticbioconversionmetabolomicsanti-diabetic activity<i>Lagerstroemia speciosa</i> L. (Banaba) |
| spellingShingle | Byung Chull An Sang Hee Kwak Jun Young Ahn Hye Yeon Won Tae Hoon Kim Yongku Ryu Myung Jun Chung Identification of Bioactive Substances Derived from the Probiotic-Induced Bioconversion of <i>Lagerstroemia speciosa</i> Pers. Leaf Extract That Have Beneficial Effects on Diabetes and Obesity Microorganisms <i>Lactobacillus plantarum</i> CBT-LP3 probiotic bioconversion metabolomics anti-diabetic activity <i>Lagerstroemia speciosa</i> L. (Banaba) |
| title | Identification of Bioactive Substances Derived from the Probiotic-Induced Bioconversion of <i>Lagerstroemia speciosa</i> Pers. Leaf Extract That Have Beneficial Effects on Diabetes and Obesity |
| title_full | Identification of Bioactive Substances Derived from the Probiotic-Induced Bioconversion of <i>Lagerstroemia speciosa</i> Pers. Leaf Extract That Have Beneficial Effects on Diabetes and Obesity |
| title_fullStr | Identification of Bioactive Substances Derived from the Probiotic-Induced Bioconversion of <i>Lagerstroemia speciosa</i> Pers. Leaf Extract That Have Beneficial Effects on Diabetes and Obesity |
| title_full_unstemmed | Identification of Bioactive Substances Derived from the Probiotic-Induced Bioconversion of <i>Lagerstroemia speciosa</i> Pers. Leaf Extract That Have Beneficial Effects on Diabetes and Obesity |
| title_short | Identification of Bioactive Substances Derived from the Probiotic-Induced Bioconversion of <i>Lagerstroemia speciosa</i> Pers. Leaf Extract That Have Beneficial Effects on Diabetes and Obesity |
| title_sort | identification of bioactive substances derived from the probiotic induced bioconversion of i lagerstroemia speciosa i pers leaf extract that have beneficial effects on diabetes and obesity |
| topic | <i>Lactobacillus plantarum</i> CBT-LP3 probiotic bioconversion metabolomics anti-diabetic activity <i>Lagerstroemia speciosa</i> L. (Banaba) |
| url | https://www.mdpi.com/2076-2607/12/9/1848 |
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