Molecular docking and quantitative structure-activity relationships for a series of Trypanosoma cruzi dihydroorotate dehydrogenase inhibitors

Molecular docking and quantitative structure-activity relationships for a series of Trypanosoma cruzi dihydroorotate dehydrogenase inhibitors

Abstract Caused by the protozoan Trypanosoma cruzi, Chagas disease affects six to seven million people worldwide, mainly in Latin America. The drugs currently available for treating the disease are ineffective during its chronic phase and have serious adverse effects. Essential for the survival of T...

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Bibliographic Details
Main Authors:	Gabriela Ciffeli de Jesus, Tatiana Santana Ribeiro, Adriano D. Andricopulo, Leonardo Luiz Gomes Ferreira
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2025-01-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Trypanosoma cruzi Medicinal chemistry QSAR Dihydroorotate dehydrogenase Inhibitors Chagas disease
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100312&lng=en&tlng=en
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