Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses

Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses

Abstract Background Metagenomics is a powerful approach for the detection of unknown and novel pathogens. Workflows based on Illumina short-read sequencing are becoming established in diagnostic laboratories. However, high sequencing depth requirements, long turnaround times, and limited sensitivity...

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Main Authors: Sarah Buddle, Leysa Forrest, Naomi Akinsuyi, Luz Marina Martin Bernal, Tony Brooks, Cristina Venturini, Charles Miller, Julianne R. Brown, Nathaniel Storey, Laura Atkinson, Timothy Best, Sunando Roy, Sian Goldsworthy, Sergi Castellano, Peter Simmonds, Heli Harvala, Tanya Golubchik, Rachel Williams, Judith Breuer, Sofia Morfopoulou, Oscar Enrique Torres Montaguth
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Genome Medicine
Subjects:
Clinical metagenomics
Viral diagnostics
Pathogen detection
Epidemiological surveillance
Next-generation sequencing
Online Access:https://doi.org/10.1186/s13073-024-01380-x
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