Comprehensive analysis of the relationships between somatometric, biochemical and clinical indicators of the condition of patients with chronic kidney diseases
Objective: To identify potential predictors of CKD based on the analysis of relationships between somatometric (including bioimpedance), biochemical and clinical parameters of patients with chronic kidney disease (CKD).Material and methods. The values of 58 parameters describing the condition of 357...
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IRBIS LLC
2023-09-01
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| Series: | Фармакоэкономика |
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| Online Access: | https://www.pharmacoeconomics.ru/jour/article/view/1167 |
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| author | I. Yu. Torshin N. Z. Bashun O. A. Gromova A. V. Chekel A. A. Levchuk S. N. Lazarevich |
| author_facet | I. Yu. Torshin N. Z. Bashun O. A. Gromova A. V. Chekel A. A. Levchuk S. N. Lazarevich |
| author_sort | I. Yu. Torshin |
| collection | DOAJ |
| description | Objective: To identify potential predictors of CKD based on the analysis of relationships between somatometric (including bioimpedance), biochemical and clinical parameters of patients with chronic kidney disease (CKD).Material and methods. The values of 58 parameters describing the condition of 357 participants were collected: 128 patients with CKD and 229 participants in the control group (without kidney pathology). Demographic, anthropometric, anamnestic data (a total of 19 diagnoses according to the International Classification of Diseases, 10th revision), bioimpedance values, results of general and biochemical blood tests (a total of 19 parameters), and diet parameters according to the CINDI questionnaire were studied. New mathematical approaches were used to establish intervals of informative values of numerical parameters, find metric concentrations in the space of biomedical research parameters and construct metric maps.Results. In the CPP group, there was a predominance of older patients (mean age 54.1±13.1 years) compared to the control group (48.78±9.75 years), as well as overweight people (82.18±19 versus 74.7±17.45 kg). Patients with CPP had impaired adipose tissue metabolism, decreased active and reactive resistance of bioimpedance, high systolic blood pressure, and multiple organ pathology.Conclusion. The analysis of the cluster of interactions of indicators allowed us to formulate promising areas for further research: it is necessary to study in more detail the informativeness and "strength" of CPP predictors, conduct a comprehensive assessment of the effectiveness of therapy, identify differences between subgroups of patients with different nosologies and stages of CPP, evaluate the effectiveness of various approaches to therapy, as well as the role of physical activity and micronutrient supply. |
| format | Article |
| id | doaj-art-e2addfb3727f4b7db288cd113d08c4df |
| institution | DOAJ |
| issn | 2070-4909 2070-4933 |
| language | Russian |
| publishDate | 2023-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Фармакоэкономика |
| spelling | doaj-art-e2addfb3727f4b7db288cd113d08c4df2025-08-20T02:58:55ZrusIRBIS LLCФармакоэкономика2070-49092070-49332023-09-010010.17749/2070-4909/farmakoekonomika.2025.295535Comprehensive analysis of the relationships between somatometric, biochemical and clinical indicators of the condition of patients with chronic kidney diseasesI. Yu. Torshin0N. Z. Bashun1O. A. Gromova2A. V. Chekel3A. A. Levchuk4S. N. Lazarevich5Federal Research Center “Computer Science and Control”, Russian Academy of SciencesYanka Kupala State University of GrodnoFederal Research Center “Computer Science and Control”, Russian Academy of SciencesYanka Kupala State University of GrodnoYanka Kupala State University of GrodnoGrodno University ClinicObjective: To identify potential predictors of CKD based on the analysis of relationships between somatometric (including bioimpedance), biochemical and clinical parameters of patients with chronic kidney disease (CKD).Material and methods. The values of 58 parameters describing the condition of 357 participants were collected: 128 patients with CKD and 229 participants in the control group (without kidney pathology). Demographic, anthropometric, anamnestic data (a total of 19 diagnoses according to the International Classification of Diseases, 10th revision), bioimpedance values, results of general and biochemical blood tests (a total of 19 parameters), and diet parameters according to the CINDI questionnaire were studied. New mathematical approaches were used to establish intervals of informative values of numerical parameters, find metric concentrations in the space of biomedical research parameters and construct metric maps.Results. In the CPP group, there was a predominance of older patients (mean age 54.1±13.1 years) compared to the control group (48.78±9.75 years), as well as overweight people (82.18±19 versus 74.7±17.45 kg). Patients with CPP had impaired adipose tissue metabolism, decreased active and reactive resistance of bioimpedance, high systolic blood pressure, and multiple organ pathology.Conclusion. The analysis of the cluster of interactions of indicators allowed us to formulate promising areas for further research: it is necessary to study in more detail the informativeness and "strength" of CPP predictors, conduct a comprehensive assessment of the effectiveness of therapy, identify differences between subgroups of patients with different nosologies and stages of CPP, evaluate the effectiveness of various approaches to therapy, as well as the role of physical activity and micronutrient supply.https://www.pharmacoeconomics.ru/jour/article/view/1167chronic kidney diseasebioimpedanceanthropometric indicatorsmetric mapbiochemical analysisclusterdiagnosis |
| spellingShingle | I. Yu. Torshin N. Z. Bashun O. A. Gromova A. V. Chekel A. A. Levchuk S. N. Lazarevich Comprehensive analysis of the relationships between somatometric, biochemical and clinical indicators of the condition of patients with chronic kidney diseases Фармакоэкономика chronic kidney disease bioimpedance anthropometric indicators metric map biochemical analysis cluster diagnosis |
| title | Comprehensive analysis of the relationships between somatometric, biochemical and clinical indicators of the condition of patients with chronic kidney diseases |
| title_full | Comprehensive analysis of the relationships between somatometric, biochemical and clinical indicators of the condition of patients with chronic kidney diseases |
| title_fullStr | Comprehensive analysis of the relationships between somatometric, biochemical and clinical indicators of the condition of patients with chronic kidney diseases |
| title_full_unstemmed | Comprehensive analysis of the relationships between somatometric, biochemical and clinical indicators of the condition of patients with chronic kidney diseases |
| title_short | Comprehensive analysis of the relationships between somatometric, biochemical and clinical indicators of the condition of patients with chronic kidney diseases |
| title_sort | comprehensive analysis of the relationships between somatometric biochemical and clinical indicators of the condition of patients with chronic kidney diseases |
| topic | chronic kidney disease bioimpedance anthropometric indicators metric map biochemical analysis cluster diagnosis |
| url | https://www.pharmacoeconomics.ru/jour/article/view/1167 |
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