QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity
Quasi-periodic patterns (QPPs) are prominent spatiotemporal brain dynamics observed in functional neuroimaging data, reflecting the alternation of high and low activity across brain regions and their propagation along cortical gradients. QPPs have been linked to neural processes such as attention, a...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | SoftwareX |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352711025000342 |
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| author | Nan Xu Behnaz Yousefi Nmachi Anumba Theodore J. LaGrow Xiaodi Zhang Shella Keilholz |
| author_facet | Nan Xu Behnaz Yousefi Nmachi Anumba Theodore J. LaGrow Xiaodi Zhang Shella Keilholz |
| author_sort | Nan Xu |
| collection | DOAJ |
| description | Quasi-periodic patterns (QPPs) are prominent spatiotemporal brain dynamics observed in functional neuroimaging data, reflecting the alternation of high and low activity across brain regions and their propagation along cortical gradients. QPPs have been linked to neural processes such as attention, arousal fluctuations, and cognitive function. Despite their significance, existing QPP analysis tools are limited by study-specific parameters and complex workflows. To address these challenges, we present QPPLab, an open-source MATLAB-based toolbox for detecting, analyzing, and visualizing QPPs from fMRI time series. QPPLab integrates correlation-based iterative algorithms, supports customizable parameter settings, and features automated workflows to simplify analysis. Processing times vary depending on dataset size and the selected mode, with the fast detection mode completing analyses that can be 4–6 times faster than the robust detection mode. Results include spatiotemporal templates of QPPs, sliding correlation time courses, and functional connectivity maps. By reducing manual parameter adjustments and providing user-friendly tools, QPPLab enables researchers to efficiently study QPPs across diverse datasets and species, advancing our understanding of intrinsic brain dynamics. |
| format | Article |
| id | doaj-art-e2ab68df87724e32a33f863ff98da772 |
| institution | Kabale University |
| issn | 2352-7110 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | SoftwareX |
| spelling | doaj-art-e2ab68df87724e32a33f863ff98da7722025-02-04T04:10:28ZengElsevierSoftwareX2352-71102025-02-0129102067QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activityNan Xu0Behnaz Yousefi1Nmachi Anumba2Theodore J. LaGrow3Xiaodi Zhang4Shella Keilholz5Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USAElectrical and Computer Engineering, Georgia Tech, Atlanta, GA, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USAQuasi-periodic patterns (QPPs) are prominent spatiotemporal brain dynamics observed in functional neuroimaging data, reflecting the alternation of high and low activity across brain regions and their propagation along cortical gradients. QPPs have been linked to neural processes such as attention, arousal fluctuations, and cognitive function. Despite their significance, existing QPP analysis tools are limited by study-specific parameters and complex workflows. To address these challenges, we present QPPLab, an open-source MATLAB-based toolbox for detecting, analyzing, and visualizing QPPs from fMRI time series. QPPLab integrates correlation-based iterative algorithms, supports customizable parameter settings, and features automated workflows to simplify analysis. Processing times vary depending on dataset size and the selected mode, with the fast detection mode completing analyses that can be 4–6 times faster than the robust detection mode. Results include spatiotemporal templates of QPPs, sliding correlation time courses, and functional connectivity maps. By reducing manual parameter adjustments and providing user-friendly tools, QPPLab enables researchers to efficiently study QPPs across diverse datasets and species, advancing our understanding of intrinsic brain dynamics.http://www.sciencedirect.com/science/article/pii/S2352711025000342Infraslow activityQuasiperiodic patternsSpatiotemporal brain dynamicsFunctional MRI |
| spellingShingle | Nan Xu Behnaz Yousefi Nmachi Anumba Theodore J. LaGrow Xiaodi Zhang Shella Keilholz QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity SoftwareX Infraslow activity Quasiperiodic patterns Spatiotemporal brain dynamics Functional MRI |
| title | QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity |
| title_full | QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity |
| title_fullStr | QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity |
| title_full_unstemmed | QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity |
| title_short | QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity |
| title_sort | qpplab a generally applicable software package for detecting analyzing and visualizing large scale quasiperiodic spatiotemporal patterns qpps of brain activity |
| topic | Infraslow activity Quasiperiodic patterns Spatiotemporal brain dynamics Functional MRI |
| url | http://www.sciencedirect.com/science/article/pii/S2352711025000342 |
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