Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab
Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several “immune-mediated” adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a histo...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2019/3614980 |
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| author | Panagiotis I. Georgianos Vasilios Vaios Eleni Leontaridou Georgia Karayannopoulou Triantafyllia Koletsa Athanasios Sioulis Elias V. Balaskas Pantelis E. Zebekakis |
| author_facet | Panagiotis I. Georgianos Vasilios Vaios Eleni Leontaridou Georgia Karayannopoulou Triantafyllia Koletsa Athanasios Sioulis Elias V. Balaskas Pantelis E. Zebekakis |
| author_sort | Panagiotis I. Georgianos |
| collection | DOAJ |
| description | Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several “immune-mediated” adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3.5 months after initiation of immunotherapy with nivolumab. Urinalysis revealed sterile pyuria, without microscopic hematuria or proteinuria. Immunological examination was negative. A renal biopsy showed severe interstitial inflammatory infiltration of T-cells, monocytes, and eosinophils without interstitial granulomas and normal appearance of glomeruli, indicating acute interstitial nephritis (AIN) as the cause of AKI. After a short-term course of corticosteroids and permanent nivolumab discontinuation, partial recovery of renal function was noted. AIN is a rare adverse effect of ICPIs that mandates the close monitoring of renal function in patients under immunotherapy with these agents. |
| format | Article |
| id | doaj-art-e29b7c9d964b486a94fb9a90da000a50 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-e29b7c9d964b486a94fb9a90da000a502025-02-03T01:24:26ZengWileyCase Reports in Nephrology2090-66412090-665X2019-01-01201910.1155/2019/36149803614980Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with NivolumabPanagiotis I. Georgianos0Vasilios Vaios1Eleni Leontaridou2Georgia Karayannopoulou3Triantafyllia Koletsa4Athanasios Sioulis5Elias V. Balaskas6Pantelis E. Zebekakis7Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceSection of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceSection of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceDepartment of Pathology, Aristotle University of Thessaloniki, Thessaloniki, GreeceDepartment of Pathology, Aristotle University of Thessaloniki, Thessaloniki, GreeceSection of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceSection of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceSection of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceImmune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several “immune-mediated” adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3.5 months after initiation of immunotherapy with nivolumab. Urinalysis revealed sterile pyuria, without microscopic hematuria or proteinuria. Immunological examination was negative. A renal biopsy showed severe interstitial inflammatory infiltration of T-cells, monocytes, and eosinophils without interstitial granulomas and normal appearance of glomeruli, indicating acute interstitial nephritis (AIN) as the cause of AKI. After a short-term course of corticosteroids and permanent nivolumab discontinuation, partial recovery of renal function was noted. AIN is a rare adverse effect of ICPIs that mandates the close monitoring of renal function in patients under immunotherapy with these agents.http://dx.doi.org/10.1155/2019/3614980 |
| spellingShingle | Panagiotis I. Georgianos Vasilios Vaios Eleni Leontaridou Georgia Karayannopoulou Triantafyllia Koletsa Athanasios Sioulis Elias V. Balaskas Pantelis E. Zebekakis Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab Case Reports in Nephrology |
| title | Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab |
| title_full | Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab |
| title_fullStr | Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab |
| title_full_unstemmed | Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab |
| title_short | Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab |
| title_sort | acute interstitial nephritis in a patient with non small cell lung cancer under immunotherapy with nivolumab |
| url | http://dx.doi.org/10.1155/2019/3614980 |
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