Treatment of hypothyroidism with levothyroxine plus slow-release liothyronine: a study protocol for a randomized controlled double-blinded clinical trial

Treatment of hypothyroidism with levothyroxine plus slow-release liothyronine: a study protocol for a randomized controlled double-blinded clinical trial

Abstract Background There are emerging controversies regarding the priority of T4 + T3 combination therapy over standard care with levothyroxine (LT4) monotherapy in the management of hypothyroid subjects. Combination therapy with a slow-release form of liothyronine (SRT3) and levothyroxine may rest...

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Main Authors: F. Azizi, A. Amouzegar, H. Abdi, M. Tohidi, S. Masoumi, D. Khalili, Y. Mehrabi, A. Zadehvakili, M. Hedayati, A. A. Momenan, L. Mehran
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Trials
Subjects:
Hypothyroidism
Levothyroxine
Slow-release liothyronine
Combination therapy
Clinical trial
Patient-reported outcomes
Online Access:https://doi.org/10.1186/s13063-025-08940-5
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