Limited evolution of the yellow fever virus 17d in a mouse infection model

Limited evolution of the yellow fever virus 17d in a mouse infection model

By infecting mice with the yellow fever virus vaccine strain 17D (YFV-17D; Stamaril®), the dose dependence and evolutionary consequences of neurotropic yellow fever infection was assessed. Highly susceptible AG129 mice were used to allow for a maximal/unlimited expansion of the viral populations. In...

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Bibliographic Details
Main Authors: Dieudonné Buh Kum, Niraj Mishra, Bram Vrancken, Hendrik Jan Thibaut, Annelies Wilder-Smith, Philippe Lemey, Johan Neyts, Kai Dallmeier
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Yellow fever virus
virus diversity
fractional dosing
YFV-17D
intra-host evolution
live-attenuated vaccine
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1694394
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