Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8
Resistin is associated with metabolic syndrome and inflammatory conditions. Many studies have suggested that resistin inhibits the accumulation of glycogen; however, the exact mechanisms of resistin-induced decrease in glycogen content remain unclear. Keratin 8 is a typical epithelial intermediate f...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/9767926 |
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| author | Fengyun Wen Qiao Xia Hui Zhang Haipeng Shia Amin Rajesh Yanling Wu Yi Yang Zaiqing Yang |
| author_facet | Fengyun Wen Qiao Xia Hui Zhang Haipeng Shia Amin Rajesh Yanling Wu Yi Yang Zaiqing Yang |
| author_sort | Fengyun Wen |
| collection | DOAJ |
| description | Resistin is associated with metabolic syndrome and inflammatory conditions. Many studies have suggested that resistin inhibits the accumulation of glycogen; however, the exact mechanisms of resistin-induced decrease in glycogen content remain unclear. Keratin 8 is a typical epithelial intermediate filament protein, but numerous studies suggest a vital role of K8 in glucose metabolism. However, it is still not known whether K8 participates in the mediation of resistin-induced reduction of cellular glycogen accumulation. In this study, we found that resistin upregulated expression of the p65 subunit of NF-κB, which led to the promotion of K8 transcriptional expression; in turn, the expression of K8 inhibited glycogen accumulation in HepG2 cells. |
| format | Article |
| id | doaj-art-e280e1c01d654d8497ccc39150d5fb65 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e280e1c01d654d8497ccc39150d5fb652025-02-03T06:07:37ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/97679269767926Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8Fengyun Wen0Qiao Xia1Hui Zhang2Haipeng Shia3Amin Rajesh4Yanling Wu5Yi Yang6Zaiqing Yang7College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, ChinaDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, 36849-5501 Auburn, Alabama, USAKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, ChinaResistin is associated with metabolic syndrome and inflammatory conditions. Many studies have suggested that resistin inhibits the accumulation of glycogen; however, the exact mechanisms of resistin-induced decrease in glycogen content remain unclear. Keratin 8 is a typical epithelial intermediate filament protein, but numerous studies suggest a vital role of K8 in glucose metabolism. However, it is still not known whether K8 participates in the mediation of resistin-induced reduction of cellular glycogen accumulation. In this study, we found that resistin upregulated expression of the p65 subunit of NF-κB, which led to the promotion of K8 transcriptional expression; in turn, the expression of K8 inhibited glycogen accumulation in HepG2 cells.http://dx.doi.org/10.1155/2020/9767926 |
| spellingShingle | Fengyun Wen Qiao Xia Hui Zhang Haipeng Shia Amin Rajesh Yanling Wu Yi Yang Zaiqing Yang Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8 International Journal of Endocrinology |
| title | Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8 |
| title_full | Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8 |
| title_fullStr | Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8 |
| title_full_unstemmed | Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8 |
| title_short | Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8 |
| title_sort | resistin activates p65 pathway and reduces glycogen content through keratin 8 |
| url | http://dx.doi.org/10.1155/2020/9767926 |
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