Potential of germanium-based compounds in coronavirus infection
The first germanium compounds which exhibited immunomodulatory and antiviral effects were sesquioxane-type germanates. To date, more than a dozen compounds containing germanium have been synthesized and are being actively studied. They include germanium carboxylates and citrates, complexes of german...
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| Format: | Article |
| Language: | English |
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Sciendo
2022-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2022-0016 |
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| author | NAROKHA VIOLETTA NIZHENKOVSKA IRYNA KUZNETSOVA OLENA |
| author_facet | NAROKHA VIOLETTA NIZHENKOVSKA IRYNA KUZNETSOVA OLENA |
| author_sort | NAROKHA VIOLETTA |
| collection | DOAJ |
| description | The first germanium compounds which exhibited immunomodulatory and antiviral effects were sesquioxane-type germanates. To date, more than a dozen compounds containing germanium have been synthesized and are being actively studied. They include germanium carboxylates and citrates, complexes of germanium with resveratrol, daphnetin, mangiferin, chrysin, quercetin, ascorbic and nicotinic acids, amino acids, gamma-lactones, germanium-containing spirulina, yeast and others. Germanium-based compounds have shown the ability to influence the replication of various DNA/RNA viruses, stimulate the body’s natural resistance, prevent the development of metabolic intoxication of various origin, increase the efficacy of vaccines, and prevent the development of excessive accumulation of reactive oxygen species, which plays a decisive role in the development of inflammatory response caused by a viral infection. It seems reasonable to say that germanium-based complex compounds effectively contribute to the preservation of high--energy bonds in the form of ATP, optimize the activity of metabolic processes by re-oxygenation, and exhibit antimicrobial activity. The purpose of this review is to summarize the pharmacological potential of various germanium-based compounds studied nowadays, taking into account their mechanisms of action, and to analyze their prospects in the development of integrated approaches in the prevention and treatment of SARS-CoV-2 infection. |
| format | Article |
| id | doaj-art-e26f466ef7014829b3ba8ac0ba12af7a |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-e26f466ef7014829b3ba8ac0ba12af7a2025-02-02T19:02:00ZengSciendoActa Pharmaceutica1846-95582022-06-0172224525810.2478/acph-2022-0016Potential of germanium-based compounds in coronavirus infectionNAROKHA VIOLETTA0NIZHENKOVSKA IRYNA1KUZNETSOVA OLENA2Department of Pharmaceutical Biological and Toxicological Chemistry Faculty of Pharmacy, Bogomolets National Medical UniversityKyiv, UkraineDepartment of Pharmaceutical Biological and Toxicological Chemistry Faculty of Pharmacy, Bogomolets National Medical UniversityKyiv, UkraineDepartment of Pharmaceutical Biological and Toxicological Chemistry Faculty of Pharmacy, Bogomolets National Medical UniversityKyiv, UkraineThe first germanium compounds which exhibited immunomodulatory and antiviral effects were sesquioxane-type germanates. To date, more than a dozen compounds containing germanium have been synthesized and are being actively studied. They include germanium carboxylates and citrates, complexes of germanium with resveratrol, daphnetin, mangiferin, chrysin, quercetin, ascorbic and nicotinic acids, amino acids, gamma-lactones, germanium-containing spirulina, yeast and others. Germanium-based compounds have shown the ability to influence the replication of various DNA/RNA viruses, stimulate the body’s natural resistance, prevent the development of metabolic intoxication of various origin, increase the efficacy of vaccines, and prevent the development of excessive accumulation of reactive oxygen species, which plays a decisive role in the development of inflammatory response caused by a viral infection. It seems reasonable to say that germanium-based complex compounds effectively contribute to the preservation of high--energy bonds in the form of ATP, optimize the activity of metabolic processes by re-oxygenation, and exhibit antimicrobial activity. The purpose of this review is to summarize the pharmacological potential of various germanium-based compounds studied nowadays, taking into account their mechanisms of action, and to analyze their prospects in the development of integrated approaches in the prevention and treatment of SARS-CoV-2 infection.https://doi.org/10.2478/acph-2022-0016germaniumorganic germaniumsars-cov-2covid-19 |
| spellingShingle | NAROKHA VIOLETTA NIZHENKOVSKA IRYNA KUZNETSOVA OLENA Potential of germanium-based compounds in coronavirus infection Acta Pharmaceutica germanium organic germanium sars-cov-2 covid-19 |
| title | Potential of germanium-based compounds in coronavirus infection |
| title_full | Potential of germanium-based compounds in coronavirus infection |
| title_fullStr | Potential of germanium-based compounds in coronavirus infection |
| title_full_unstemmed | Potential of germanium-based compounds in coronavirus infection |
| title_short | Potential of germanium-based compounds in coronavirus infection |
| title_sort | potential of germanium based compounds in coronavirus infection |
| topic | germanium organic germanium sars-cov-2 covid-19 |
| url | https://doi.org/10.2478/acph-2022-0016 |
| work_keys_str_mv | AT narokhavioletta potentialofgermaniumbasedcompoundsincoronavirusinfection AT nizhenkovskairyna potentialofgermaniumbasedcompoundsincoronavirusinfection AT kuznetsovaolena potentialofgermaniumbasedcompoundsincoronavirusinfection |