Laherradurin Inhibits Colorectal Cancer Cell Growth by Induction of Mitochondrial Dysfunction and Autophagy Induction

Laherradurin Inhibits Colorectal Cancer Cell Growth by Induction of Mitochondrial Dysfunction and Autophagy Induction

LAH, an acetogenin from the Annonaceae family, has demonstrated antitumor activity in several cancer cell lines and in vivo models, where it reduced the tumor size and induced programmed cell death. We focused on the effects of LAH on mitochondrial dynamics, mTOR signaling, autophagy, and apoptosis...

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Main Authors: Izamary Delgado-Waldo, Svetlana Dokudovskaya, Yahir A. Loissell-Baltazar, Eduardo Pérez-Arteaga, Jossimar Coronel-Hernández, Mariano Martínez-Vázquez, Eloy Andrés Pérez-Yépez, Alejandro Lopez-Saavedra, Nadia Jacobo-Herrera, Carlos Pérez Plasencia
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
laherradurin
acetogenins
colon cancer
mitochondria
autophagy
apoptosis
Online Access:https://www.mdpi.com/2073-4409/13/19/1649
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https://www.mdpi.com/2073-4409/13/19/1649

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