Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity

Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity

Protein disulfide isomerase (PDI) is a member of the thioredoxin superfamily of redox enzymes. PDI is a multifunctional protein that catalyzes disulfide bond formation, cleavage, and rearrangement in unfolded or misfolded proteins and functions as a chaperone in the endoplasmic reticulum. Besides ac...

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Bibliographic Details
Main Authors:	Mariateresa Badolato, Gabriele Carullo, Francesca Aiello, Antonio Garofalo
Format:	Article
Language:	English
Published:	Wiley 2017-01-01
Series:	Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2017/2370359
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