A highly sensitive screening system to evaluate the reversibility of neuroendocrine prostate cancer to prostate adenocarcinoma

A highly sensitive screening system to evaluate the reversibility of neuroendocrine prostate cancer to prostate adenocarcinoma

Abstract Background Lineage plasticity in prostate cancer primarily induces transdifferentiation of adenocarcinoma into neuroendocrine prostate cancer (NEPC). Lineage alteration is largely driven by epigenome and is potentially reversible. Nonetheless, evidence supporting NEPC reversibility is lacki...

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Main Authors: Tomohiro Fukui, Kosuke Okasho, Yukiko Okuno, Maki Fujiwara, Kensuke Hikami, Arinobu Fukunaga, Takuro Sunada, Yuki Kita, Takayuki Sumiyoshi, Takayuki Goto, Ryoichi Saito, Osamu Ogawa, Takashi Kobayashi, Shusuke Akamatsu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Cancer Medicine
Online Access:https://doi.org/10.1002/cam4.70047
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