Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia
Background. Adherence to antiviral therapy is important for HIV-infected people living in low- and middle-income countries, because of poor access to alternative regimens. Methods. We conducted a cross-sectional survey of adherence in Cambodian patients enrolled in the ESTHER program and treated wit...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2010/142076 |
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| author | Olivier Segeral Yoann Madec Boroath Ban Vara Ouk Chan Roeurn Hak Clotilde Le Tiec Eric Nerrienet Cécile Goujard Anne Marie Taburet Jean Francois Delfraissy Arnaud Fontanet |
| author_facet | Olivier Segeral Yoann Madec Boroath Ban Vara Ouk Chan Roeurn Hak Clotilde Le Tiec Eric Nerrienet Cécile Goujard Anne Marie Taburet Jean Francois Delfraissy Arnaud Fontanet |
| author_sort | Olivier Segeral |
| collection | DOAJ |
| description | Background. Adherence to antiviral therapy is important for HIV-infected people living in low- and middle-income countries, because of poor access to alternative regimens. Methods. We conducted a cross-sectional survey of adherence in Cambodian patients enrolled in the ESTHER program and treated with WHO first-line regimen for at least 6 months. The survey was based on a self-report questionnaire, drug assay, MCV measurement, visual analog scale, and viral load HIV RNA. Results. Two hundred fifty-nine patients treated for a median of 16 months participated in the survey. At inclusion in the program, 158 patients (61%) were ARV-naïve. The virological success rate was 71% overall and 81% in previously ARV-naive patients. Considered individually, the measures suggested perfect adherence in 71% to 93% of patients. In multivariate analysis adjusted for sex and therapeutic status before HAART initiation, only the biological markers were associated with virological efficacy. Self-funded treatment before entry to the program was highly predictive of virological failure. Conclusion. Adherence was excellent in these Cambodian patients. Biological markers were predictive of virological efficacy. MCV might thus serve as a simple alternative for assessing adherence and predicting virological efficacy among patients receiving AZT- or d4T-based regimens. |
| format | Article |
| id | doaj-art-e24a3d9bed2d4bc4bffe2a6f9933a260 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-e24a3d9bed2d4bc4bffe2a6f9933a2602025-02-03T01:03:36ZengWileyAIDS Research and Treatment2090-12402090-12592010-01-01201010.1155/2010/142076142076Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in CambodiaOlivier Segeral0Yoann Madec1Boroath Ban2Vara Ouk3Chan Roeurn Hak4Clotilde Le Tiec5Eric Nerrienet6Cécile Goujard7Anne Marie Taburet8Jean Francois Delfraissy9Arnaud Fontanet10Service de Médecine Interne, Centre Hospitalier Universitaire de Bicêtre, AP-HP, 94270 Le Kremlin Bicêtre, FranceUnité d'Epidémiologie des maladies émergentes, Institut Pasteur, 75015 Paris, FranceService de Maladies Infectieuses, Hôpital Calmette, 12100 Phnom-Penh, CambodiaService de Maladies Infectieuses, Hôpital Calmette, 12100 Phnom-Penh, CambodiaService de Maladies Infectieuses, Hôpital Calmette, 12100 Phnom-Penh, CambodiaService de Pharmacologie, Centre Hospitalier Universitaire de Bicêtre, AP-HP, 94270 Le Kremlin Bicêtre, FranceLaboratoire VIH/Hépatites, Institut Pasteur, 12100 Phnom-Penh, CambodiaService de Médecine Interne, Centre Hospitalier Universitaire de Bicêtre, AP-HP, 94270 Le Kremlin Bicêtre, FranceService de Pharmacologie, Centre Hospitalier Universitaire de Bicêtre, AP-HP, 94270 Le Kremlin Bicêtre, FranceService de Médecine Interne, Centre Hospitalier Universitaire de Bicêtre, AP-HP, 94270 Le Kremlin Bicêtre, FranceUnité d'Epidémiologie des maladies émergentes, Institut Pasteur, 75015 Paris, FranceBackground. Adherence to antiviral therapy is important for HIV-infected people living in low- and middle-income countries, because of poor access to alternative regimens. Methods. We conducted a cross-sectional survey of adherence in Cambodian patients enrolled in the ESTHER program and treated with WHO first-line regimen for at least 6 months. The survey was based on a self-report questionnaire, drug assay, MCV measurement, visual analog scale, and viral load HIV RNA. Results. Two hundred fifty-nine patients treated for a median of 16 months participated in the survey. At inclusion in the program, 158 patients (61%) were ARV-naïve. The virological success rate was 71% overall and 81% in previously ARV-naive patients. Considered individually, the measures suggested perfect adherence in 71% to 93% of patients. In multivariate analysis adjusted for sex and therapeutic status before HAART initiation, only the biological markers were associated with virological efficacy. Self-funded treatment before entry to the program was highly predictive of virological failure. Conclusion. Adherence was excellent in these Cambodian patients. Biological markers were predictive of virological efficacy. MCV might thus serve as a simple alternative for assessing adherence and predicting virological efficacy among patients receiving AZT- or d4T-based regimens.http://dx.doi.org/10.1155/2010/142076 |
| spellingShingle | Olivier Segeral Yoann Madec Boroath Ban Vara Ouk Chan Roeurn Hak Clotilde Le Tiec Eric Nerrienet Cécile Goujard Anne Marie Taburet Jean Francois Delfraissy Arnaud Fontanet Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia AIDS Research and Treatment |
| title | Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia |
| title_full | Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia |
| title_fullStr | Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia |
| title_full_unstemmed | Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia |
| title_short | Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia |
| title_sort | simplified assessment of antiretroviral adherence and prediction of virological efficacy in hiv infected patients in cambodia |
| url | http://dx.doi.org/10.1155/2010/142076 |
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