The Application of Mechanical Stimulations in Tendon Tissue Engineering
Tendon injury is the most common disease in the musculoskeletal system. The current treatment methods have many limitations, such as poor therapeutic effects, functional loss of donor site, and immune rejection. Tendon tissue engineering provides a new treatment strategy for tendon repair and regene...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8824783 |
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| _version_ | 1832566511932276736 |
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| author | Renwang Sheng Yujie Jiang Ludvig J. Backman Wei Zhang Jialin Chen |
| author_facet | Renwang Sheng Yujie Jiang Ludvig J. Backman Wei Zhang Jialin Chen |
| author_sort | Renwang Sheng |
| collection | DOAJ |
| description | Tendon injury is the most common disease in the musculoskeletal system. The current treatment methods have many limitations, such as poor therapeutic effects, functional loss of donor site, and immune rejection. Tendon tissue engineering provides a new treatment strategy for tendon repair and regeneration. In this review, we made a retrospective analysis of applying mechanical stimulation in tendon tissue engineering, and its potential as a direction of development for future clinical treatment strategies. For this purpose, the following topics are discussed; (1) the context of tendon tissue engineering and mechanical stimulation; (2) the applications of various mechanical stimulations in tendon tissue engineering, as well as their inherent mechanisms; (3) the application of magnetic force and the synergy of mechanical and biochemical stimulation. With this, we aim at clarifying some of the main questions that currently exist in the field of tendon tissue engineering and consequently gain new knowledge that may help in the development of future clinical application of tissue engineering in tendon injury. |
| format | Article |
| id | doaj-art-e2486c2ecfc142e1875428b0ceb28a64 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e2486c2ecfc142e1875428b0ceb28a642025-02-03T01:04:00ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88247838824783The Application of Mechanical Stimulations in Tendon Tissue EngineeringRenwang Sheng0Yujie Jiang1Ludvig J. Backman2Wei Zhang3Jialin Chen4School of Medicine, Southeast University, 210009 Nanjing, ChinaSchool of Medicine, Southeast University, 210009 Nanjing, ChinaDepartment of Integrative Medical Biology, Anatomy, Umeå University, SE-901 87 Umeå, SwedenSchool of Medicine, Southeast University, 210009 Nanjing, ChinaSchool of Medicine, Southeast University, 210009 Nanjing, ChinaTendon injury is the most common disease in the musculoskeletal system. The current treatment methods have many limitations, such as poor therapeutic effects, functional loss of donor site, and immune rejection. Tendon tissue engineering provides a new treatment strategy for tendon repair and regeneration. In this review, we made a retrospective analysis of applying mechanical stimulation in tendon tissue engineering, and its potential as a direction of development for future clinical treatment strategies. For this purpose, the following topics are discussed; (1) the context of tendon tissue engineering and mechanical stimulation; (2) the applications of various mechanical stimulations in tendon tissue engineering, as well as their inherent mechanisms; (3) the application of magnetic force and the synergy of mechanical and biochemical stimulation. With this, we aim at clarifying some of the main questions that currently exist in the field of tendon tissue engineering and consequently gain new knowledge that may help in the development of future clinical application of tissue engineering in tendon injury.http://dx.doi.org/10.1155/2020/8824783 |
| spellingShingle | Renwang Sheng Yujie Jiang Ludvig J. Backman Wei Zhang Jialin Chen The Application of Mechanical Stimulations in Tendon Tissue Engineering Stem Cells International |
| title | The Application of Mechanical Stimulations in Tendon Tissue Engineering |
| title_full | The Application of Mechanical Stimulations in Tendon Tissue Engineering |
| title_fullStr | The Application of Mechanical Stimulations in Tendon Tissue Engineering |
| title_full_unstemmed | The Application of Mechanical Stimulations in Tendon Tissue Engineering |
| title_short | The Application of Mechanical Stimulations in Tendon Tissue Engineering |
| title_sort | application of mechanical stimulations in tendon tissue engineering |
| url | http://dx.doi.org/10.1155/2020/8824783 |
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