Preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case series
Abstract Background Pediatric acute liver failure (PALF) is a life-threatening condition with no definitive treatment. This study evaluated the combined use of the dual plasma molecular adsorption system (DPMAS) and plasma exchange (PE) to improve liver function and survival outcomes in PALF patient...
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BMC
2025-03-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-025-05520-z |
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| author | Jia-Hao Geng Shi-Lin Liu Bao-Fan Dou Jun-Lin Zhao He-Kai Ma Zhi-Yuan Wang Shu-Jun Li |
| author_facet | Jia-Hao Geng Shi-Lin Liu Bao-Fan Dou Jun-Lin Zhao He-Kai Ma Zhi-Yuan Wang Shu-Jun Li |
| author_sort | Jia-Hao Geng |
| collection | DOAJ |
| description | Abstract Background Pediatric acute liver failure (PALF) is a life-threatening condition with no definitive treatment. This study evaluated the combined use of the dual plasma molecular adsorption system (DPMAS) and plasma exchange (PE) to improve liver function and survival outcomes in PALF patients. Methods A retrospective study was conducted on 7 PALF patients treated with DPMAS and PE. Data on liver function scores (Liver Injury Unit [LIU], Model for End-Stage Liver Disease [MELD], Model for End-Stage Liver Disease with Sodium [MELD-Na], MELD 3.0), bilirubin levels, and coagulation indices were collected before and after treatment. Results DPMAS and PE treatments significantly reduced total bilirubin (382.2 µmol/L to 52.0 µmol/L) and improved coagulation indices. Liver injury scores decreased notably (e.g., LIU from 184 to 52 in one case). Five patients recovered, while two with severe comorbidities showed limited improvement. Conclusion The combination of DPMAS and PE therapy improves liver function and survival outcomes in PALF. These results support its use as a bridge to recovery or transplantation in PALF patients, though further studies with larger sample sizes are needed. |
| format | Article |
| id | doaj-art-e231ef36bc3a42c7bb72b8ce3f5280f4 |
| institution | DOAJ |
| issn | 1471-2431 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj-art-e231ef36bc3a42c7bb72b8ce3f5280f42025-08-20T02:59:57ZengBMCBMC Pediatrics1471-24312025-03-012511710.1186/s12887-025-05520-zPreliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case seriesJia-Hao Geng0Shi-Lin Liu1Bao-Fan Dou2Jun-Lin Zhao3He-Kai Ma4Zhi-Yuan Wang5Shu-Jun Li6Department of Pediatrics, The First Affiliated Hospital of Xinxiang Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical UniversityAbstract Background Pediatric acute liver failure (PALF) is a life-threatening condition with no definitive treatment. This study evaluated the combined use of the dual plasma molecular adsorption system (DPMAS) and plasma exchange (PE) to improve liver function and survival outcomes in PALF patients. Methods A retrospective study was conducted on 7 PALF patients treated with DPMAS and PE. Data on liver function scores (Liver Injury Unit [LIU], Model for End-Stage Liver Disease [MELD], Model for End-Stage Liver Disease with Sodium [MELD-Na], MELD 3.0), bilirubin levels, and coagulation indices were collected before and after treatment. Results DPMAS and PE treatments significantly reduced total bilirubin (382.2 µmol/L to 52.0 µmol/L) and improved coagulation indices. Liver injury scores decreased notably (e.g., LIU from 184 to 52 in one case). Five patients recovered, while two with severe comorbidities showed limited improvement. Conclusion The combination of DPMAS and PE therapy improves liver function and survival outcomes in PALF. These results support its use as a bridge to recovery or transplantation in PALF patients, though further studies with larger sample sizes are needed.https://doi.org/10.1186/s12887-025-05520-zPediatric acute liver failurePlasma exchangeDual plasma molecular adsorption systemHyperbilirubinemiaLiver function |
| spellingShingle | Jia-Hao Geng Shi-Lin Liu Bao-Fan Dou Jun-Lin Zhao He-Kai Ma Zhi-Yuan Wang Shu-Jun Li Preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case series BMC Pediatrics Pediatric acute liver failure Plasma exchange Dual plasma molecular adsorption system Hyperbilirubinemia Liver function |
| title | Preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case series |
| title_full | Preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case series |
| title_fullStr | Preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case series |
| title_full_unstemmed | Preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case series |
| title_short | Preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure: a retrospective case series |
| title_sort | preliminary experience of combined dual plasma molecular adsorption system and plasma exchange in pediatric acute liver failure a retrospective case series |
| topic | Pediatric acute liver failure Plasma exchange Dual plasma molecular adsorption system Hyperbilirubinemia Liver function |
| url | https://doi.org/10.1186/s12887-025-05520-z |
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