Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways

Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways

Abstract Background Dry eye disease (DED) predominantly results from elevated tear film osmolarity, which can not only cause ocular inconvenience but may lead to visual impairments, severely compromising patient well‐being and exerting substantial economic burdens as well. Astaxanthin (AST), a membe...

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Bibliographic Details
Main Authors: Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Animal Models and Experimental Medicine
Subjects:
astaxanthin
dry eye disease
human corneal epithelial cell
Keap1‐Nrf2/HO‐1 pathway
network pharmacology
oxidative stress
Online Access:https://doi.org/10.1002/ame2.70000
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