Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding
Background. Recent data demonstrated that the −174 G>C IL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery. Objective. We investigated the impact of −174 G>C IL-6 polymorphism on weight loss, body composition, and...
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Wiley
2012-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/208953 |
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| author | Laura Di Renzo Maria Grazia Carbonelli Alessia Bianchi Emidio Domino Maria Rita Migliore Guido Rillo Leonardo Iacopino Nicola Di Daniele Antonino De Lorenzo |
| author_facet | Laura Di Renzo Maria Grazia Carbonelli Alessia Bianchi Emidio Domino Maria Rita Migliore Guido Rillo Leonardo Iacopino Nicola Di Daniele Antonino De Lorenzo |
| author_sort | Laura Di Renzo |
| collection | DOAJ |
| description | Background. Recent data demonstrated that the −174 G>C IL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery. Objective. We investigated the impact of −174 G>C IL-6 polymorphism on weight loss, body composition, and fluid distribution changes in obese subjects after LAGB. Design and Outcome Measures. Twenty obese subjects were selected and studied at baseline and 3 months after LAGB. Genetic assessment of −174 G>C IL-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed. Results. At baseline, C(+) carriers had a lower extracellular water (ECW) and higher intra-CW, phase angle (PA), reactance Xc, and Xc/height. LAGB surgery determined significant reductions in weight and BMI. After LAGB, in C(−) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, and Xc/H were highlighted. In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), and R/height were obtained. Significant higher reductions in BMI and Xc/H were observed in C(+) with respect to C(−) carriers. Conclusions. Genotyping of genetic variants, for example, the −174 G>C polymorphism of IL-6, gives the opportunity to predict therapeutic response, in terms of body composition outcomes after LAGB. |
| format | Article |
| id | doaj-art-e222f8aaaf7844b2a7c02c891fb58145 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-e222f8aaaf7844b2a7c02c891fb581452025-02-03T05:45:55ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/208953208953Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric BandingLaura Di Renzo0Maria Grazia Carbonelli1Alessia Bianchi2Emidio Domino3Maria Rita Migliore4Guido Rillo5Leonardo Iacopino6Nicola Di Daniele7Antonino De Lorenzo8Division of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, ItalyDietology and nutrition Unit, San Camillo-Forlanini Hospital, 00151 Rome, ItalyDivision of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, ItalyDivision of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, ItalyDivision of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, ItalyDivision of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, ItalyDivision of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Internal Medicine, University of Tor Vergata, 00133 Rome, ItalyDivision of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, ItalyBackground. Recent data demonstrated that the −174 G>C IL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery. Objective. We investigated the impact of −174 G>C IL-6 polymorphism on weight loss, body composition, and fluid distribution changes in obese subjects after LAGB. Design and Outcome Measures. Twenty obese subjects were selected and studied at baseline and 3 months after LAGB. Genetic assessment of −174 G>C IL-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed. Results. At baseline, C(+) carriers had a lower extracellular water (ECW) and higher intra-CW, phase angle (PA), reactance Xc, and Xc/height. LAGB surgery determined significant reductions in weight and BMI. After LAGB, in C(−) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, and Xc/H were highlighted. In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), and R/height were obtained. Significant higher reductions in BMI and Xc/H were observed in C(+) with respect to C(−) carriers. Conclusions. Genotyping of genetic variants, for example, the −174 G>C polymorphism of IL-6, gives the opportunity to predict therapeutic response, in terms of body composition outcomes after LAGB.http://dx.doi.org/10.1155/2012/208953 |
| spellingShingle | Laura Di Renzo Maria Grazia Carbonelli Alessia Bianchi Emidio Domino Maria Rita Migliore Guido Rillo Leonardo Iacopino Nicola Di Daniele Antonino De Lorenzo Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding Journal of Obesity |
| title | Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding |
| title_full | Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding |
| title_fullStr | Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding |
| title_full_unstemmed | Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding |
| title_short | Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding |
| title_sort | impact of the 174 g c il 6 polymorphism on bioelectrical parameters in obese subjects after laparoscopic adjustable gastric banding |
| url | http://dx.doi.org/10.1155/2012/208953 |
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