USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression

USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression

Abstract Background Intracellular membraneless organelles formed by liquid-liquid phase separation (LLPS) function in diverse physiological processes and have been linked to tumor-promoting properties. The nucleolus is one of the largest membraneless organelle formed through LLPS. Deubiquitylating e...

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Main Authors: Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, Han Liu, Zhaoxia Dai, Shu-Lan Sun, Shuyan Liu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
LLPS
Nucleolus
USP39
GLI1
Lung adenocarcinoma
Online Access:https://doi.org/10.1186/s12964-025-02059-5
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