Motor Function in Irritable Bowel Syndrome
The evidence supporting a role of abnormal motor function in irritable bowel syndrome (IBS) is reviewed. Symptoms commonly present in IBS patients, such as vomiting, diarrhea, constipation or incomplete rectal evacuation, indicate that a motor disorder is implicit as either a primary or secondary di...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1999-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1999/240329 |
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| Summary: | The evidence supporting
a role of abnormal motor function in irritable bowel syndrome
(IBS) is reviewed. Symptoms commonly present in IBS
patients, such as vomiting, diarrhea, constipation or incomplete
rectal evacuation, indicate that a motor disorder is implicit as either
a primary or secondary disturbance. Physiological studies implicate
a disturbance of transit through the small bowel and
proximal colon, and abnormal motor responses of the rectum to
distention in IBS patients. Intestinal contractions (physiological
or ‘abnormal’) are associated with the sensation of pain, suggesting
that these contractions are interactions between abnormal motor
and sensory functions in IBS. Therapies aimed at correcting abnormal
transit or antispasmodics are the main pharmacological
approaches to the relief of IBS, and, although the latter are not always
effective in the long term response to treatment, they support
the role of dysmotility in IBS. Most novel therapies under trial
probably modulate both sensory and motor functions, and are discussed
briefly. In summary, the weight of clinical, physiological
and pharmacological evidence supports a role of abnormal motility
in IBS. |
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| ISSN: | 0835-7900 |