Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center Experience
Background and Aims. Endoscopic removal of GISTs (gastrointestinal stromal tumors) is recently recognized, but less is known about its efficacy and safety. This study is aimed at assessing the feasibility, clinical efficacy, and safety of the endoscopic removal of gastric GISTs. Patients and Methods...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/3087298 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546025592586240 |
|---|---|
| author | Yingjie Guo Xue Jing Jian Zhang Xueli Ding Xiaoyu Li Tao Mao Zibin Tian |
| author_facet | Yingjie Guo Xue Jing Jian Zhang Xueli Ding Xiaoyu Li Tao Mao Zibin Tian |
| author_sort | Yingjie Guo |
| collection | DOAJ |
| description | Background and Aims. Endoscopic removal of GISTs (gastrointestinal stromal tumors) is recently recognized, but less is known about its efficacy and safety. This study is aimed at assessing the feasibility, clinical efficacy, and safety of the endoscopic removal of gastric GISTs. Patients and Methods. Endoscopic removal (ER) of GISTs was performed in 134 patients at our hospital between January 2015 and January 2019. The clinical features, surgical outcomes, complications, pathological diagnosis, and risk classification were evaluated retrospectively. Results. ER was successful in 131 cases (98%), including 58 by ESD (endoscopic submucosal dissection), 43 by ESE (endoscopic submucosal excavation), 25 by EFTR (endoscopic full-thickness resection), and 5 by STER (submucosal tunneling endoscopic resection). In addition, GISTs of two cases were resected using LECS (laparoscopic and luminal endoscopic cooperative surgery) for the extraluminal and intraluminal growth pattern. The average tumor size was 1.89±1.25 cm (range: 0.5-6.0 cm). Of these patients, 26 cases had a large tumor size (range: 2.0-6.0 cm), and endoscopic removal was successful in all of them. During the procedure, endoclips were used to close the perforation in all cases, without conversion to open surgery. The average length of hospital stay was 5.50±2.15 days (range: 3-10 days). In the risk classification, 106 (79.7%) were of a very low risk, 25 (18.8%) of a low risk, and 2 (1.5%) of a moderate risk. The moderate-risk cases were treated with imatinib mesylate after ER. No recurrence or metastasis was observed during the follow-up period of 23±8 months (range: 3-48 months). Conclusions. The endoscopic treatment is feasible, effective, and safe for gastric GISTs, and individualized choice of approaches is recommended for GISTs. |
| format | Article |
| id | doaj-art-e21a555f2a2e4c259ea7ea3a600ec4fd |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e21a555f2a2e4c259ea7ea3a600ec4fd2025-02-03T07:24:07ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/30872983087298Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center ExperienceYingjie Guo0Xue Jing1Jian Zhang2Xueli Ding3Xiaoyu Li4Tao Mao5Zibin Tian6Department of Gastroenterology, The Affiliated Hospital of QingDao University, Qingdao, 266003 Shandong Province, ChinaDepartment of Gastroenterology, The Affiliated Hospital of QingDao University, Qingdao, 266003 Shandong Province, ChinaDepartment of General Surgery, The Affiliated Hospital of QingDao University, Qingdao, 266003 Shandong Province, ChinaDepartment of Gastroenterology, The Affiliated Hospital of QingDao University, Qingdao, 266003 Shandong Province, ChinaDepartment of Gastroenterology, The Affiliated Hospital of QingDao University, Qingdao, 266003 Shandong Province, ChinaDepartment of Gastroenterology, The Affiliated Hospital of QingDao University, Qingdao, 266003 Shandong Province, ChinaDepartment of Gastroenterology, The Affiliated Hospital of QingDao University, Qingdao, 266003 Shandong Province, ChinaBackground and Aims. Endoscopic removal of GISTs (gastrointestinal stromal tumors) is recently recognized, but less is known about its efficacy and safety. This study is aimed at assessing the feasibility, clinical efficacy, and safety of the endoscopic removal of gastric GISTs. Patients and Methods. Endoscopic removal (ER) of GISTs was performed in 134 patients at our hospital between January 2015 and January 2019. The clinical features, surgical outcomes, complications, pathological diagnosis, and risk classification were evaluated retrospectively. Results. ER was successful in 131 cases (98%), including 58 by ESD (endoscopic submucosal dissection), 43 by ESE (endoscopic submucosal excavation), 25 by EFTR (endoscopic full-thickness resection), and 5 by STER (submucosal tunneling endoscopic resection). In addition, GISTs of two cases were resected using LECS (laparoscopic and luminal endoscopic cooperative surgery) for the extraluminal and intraluminal growth pattern. The average tumor size was 1.89±1.25 cm (range: 0.5-6.0 cm). Of these patients, 26 cases had a large tumor size (range: 2.0-6.0 cm), and endoscopic removal was successful in all of them. During the procedure, endoclips were used to close the perforation in all cases, without conversion to open surgery. The average length of hospital stay was 5.50±2.15 days (range: 3-10 days). In the risk classification, 106 (79.7%) were of a very low risk, 25 (18.8%) of a low risk, and 2 (1.5%) of a moderate risk. The moderate-risk cases were treated with imatinib mesylate after ER. No recurrence or metastasis was observed during the follow-up period of 23±8 months (range: 3-48 months). Conclusions. The endoscopic treatment is feasible, effective, and safe for gastric GISTs, and individualized choice of approaches is recommended for GISTs.http://dx.doi.org/10.1155/2019/3087298 |
| spellingShingle | Yingjie Guo Xue Jing Jian Zhang Xueli Ding Xiaoyu Li Tao Mao Zibin Tian Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center Experience Gastroenterology Research and Practice |
| title | Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center Experience |
| title_full | Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center Experience |
| title_fullStr | Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center Experience |
| title_full_unstemmed | Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center Experience |
| title_short | Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center Experience |
| title_sort | endoscopic removal of gastrointestinal stromal tumors in the stomach a single center experience |
| url | http://dx.doi.org/10.1155/2019/3087298 |
| work_keys_str_mv | AT yingjieguo endoscopicremovalofgastrointestinalstromaltumorsinthestomachasinglecenterexperience AT xuejing endoscopicremovalofgastrointestinalstromaltumorsinthestomachasinglecenterexperience AT jianzhang endoscopicremovalofgastrointestinalstromaltumorsinthestomachasinglecenterexperience AT xueliding endoscopicremovalofgastrointestinalstromaltumorsinthestomachasinglecenterexperience AT xiaoyuli endoscopicremovalofgastrointestinalstromaltumorsinthestomachasinglecenterexperience AT taomao endoscopicremovalofgastrointestinalstromaltumorsinthestomachasinglecenterexperience AT zibintian endoscopicremovalofgastrointestinalstromaltumorsinthestomachasinglecenterexperience |