Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungi Alternaria alternata BRN05 isolated from seeds of Swietenia macrophylla king

Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungi Alternaria alternata BRN05 isolated from seeds of Swietenia macrophylla king

There is a growing demand for new diabetes drugs with fewer side effects to replace current medications known for their adverse effects. Inhibition of α-glucosidase responsible for postprandial hyperglycemia among diabetes patients is a promising strategy for managing the disease. This study aims to...

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Main Authors: Piyush Kumar, Sai Anand Kannakazhi Kantari, Ranendra Pratap Biswal, Prasanth Ghanta, Malleswara Dharanikota
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Fungal Biology
Subjects:
α-glucosidase inhibitors
Alternaria alternata
full-strength media (FS)
quarter-strength media (QS)
diabetes
ultra-high-performance liquid chromatography - electrospray ionization - quadrupole time-of-flight mass spectrometry (UHPLC-ESI-QTOF-MS)
Online Access:https://www.frontiersin.org/articles/10.3389/ffunb.2025.1447609/full
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https://www.frontiersin.org/articles/10.3389/ffunb.2025.1447609/full

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