Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity
Background. Maternal metabolic changes impact fetal metabolism resulting in a higher risk for developing chronic diseases later in life. The aim of this study was to assess the association between maternal and fetal adipokine and lipid profiles, as well as the influence of maternal weight on this as...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/7015626 |
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| author | Mario Solis-Paredes Salvador Espino y Sosa Guadalupe Estrada-Gutierrez Sonia Nava-Salazar Veronica Ortega-Castillo Mario Rodriguez-Bosch Eyerahi Bravo-Flores Aurora Espejel-Nuñez Maricruz Tolentino-Dolores Rubí Gaona-Estudillo Nancy Martinez-Bautista Otilia Perichart-Perera |
| author_facet | Mario Solis-Paredes Salvador Espino y Sosa Guadalupe Estrada-Gutierrez Sonia Nava-Salazar Veronica Ortega-Castillo Mario Rodriguez-Bosch Eyerahi Bravo-Flores Aurora Espejel-Nuñez Maricruz Tolentino-Dolores Rubí Gaona-Estudillo Nancy Martinez-Bautista Otilia Perichart-Perera |
| author_sort | Mario Solis-Paredes |
| collection | DOAJ |
| description | Background. Maternal metabolic changes impact fetal metabolism resulting in a higher risk for developing chronic diseases later in life. The aim of this study was to assess the association between maternal and fetal adipokine and lipid profiles, as well as the influence of maternal weight on this association. Methods. Healthy pregnant women at term who delivered by C-section were enrolled. Maternal and fetal glucose, lipid profile, adiponectin, leptin, and resistin levels were analyzed by obesity and maternal weight gain. Statistics included descriptives, correlations, and mean differences (SPSS v20.0). Results. Adiponectin and resistin concentrations were higher in fetal blood, while leptin was lower (p<0.05). A significant inverse association between maternal resistin and fetal LDL-cholesterol (LDL-C) (r=-0.327; p=0.022) was observed. A positive correlation was found between maternal and fetal resistin (r=0.358; p=0.013). Women with excessive weight gain had higher leptin levels and their fetuses showed higher LDL-C levels (p<0.05). Conclusions. Maternal resistin showed an inverse association with fetal LDL-C, suggesting that maternal adiposity status may play an active role in the regulation of fetal lipid profile and consequently, in fetal programming. Excessive maternal weight gain during pregnancy may exert an effect over metabolic mediators in both mother and newborn. |
| format | Article |
| id | doaj-art-e21220115e084acf922ffcb2d75d3123 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e21220115e084acf922ffcb2d75d31232025-02-03T01:28:59ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/70156267015626Maternal and Fetal Lipid and Adipokine Profiles and Their Association with ObesityMario Solis-Paredes0Salvador Espino y Sosa1Guadalupe Estrada-Gutierrez2Sonia Nava-Salazar3Veronica Ortega-Castillo4Mario Rodriguez-Bosch5Eyerahi Bravo-Flores6Aurora Espejel-Nuñez7Maricruz Tolentino-Dolores8Rubí Gaona-Estudillo9Nancy Martinez-Bautista10Otilia Perichart-Perera11Department of Immunobiochemistry, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoDirection of Education, Instituto Nacional de Medicina Genomica, 14610 Ciudad de México, DF, MexicoBiomedical Research Branch, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoDepartment of Immunobiochemistry, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoDepartment of Obstetrics, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoDepartment of Obstetrics, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoDepartment of Immunobiochemistry, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoDepartment of Immunobiochemistry, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoDepartment of Nutrition and Bioprogramming, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoDepartment of Immunobiochemistry, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoImmunology Department, Centro Medico Nacional La Raza, Instituto Mexicano del Seguro Social, 02990 Ciudad de México, DF, MexicoDepartment of Nutrition and Bioprogramming, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, 11000 Ciudad de México, DF, MexicoBackground. Maternal metabolic changes impact fetal metabolism resulting in a higher risk for developing chronic diseases later in life. The aim of this study was to assess the association between maternal and fetal adipokine and lipid profiles, as well as the influence of maternal weight on this association. Methods. Healthy pregnant women at term who delivered by C-section were enrolled. Maternal and fetal glucose, lipid profile, adiponectin, leptin, and resistin levels were analyzed by obesity and maternal weight gain. Statistics included descriptives, correlations, and mean differences (SPSS v20.0). Results. Adiponectin and resistin concentrations were higher in fetal blood, while leptin was lower (p<0.05). A significant inverse association between maternal resistin and fetal LDL-cholesterol (LDL-C) (r=-0.327; p=0.022) was observed. A positive correlation was found between maternal and fetal resistin (r=0.358; p=0.013). Women with excessive weight gain had higher leptin levels and their fetuses showed higher LDL-C levels (p<0.05). Conclusions. Maternal resistin showed an inverse association with fetal LDL-C, suggesting that maternal adiposity status may play an active role in the regulation of fetal lipid profile and consequently, in fetal programming. Excessive maternal weight gain during pregnancy may exert an effect over metabolic mediators in both mother and newborn.http://dx.doi.org/10.1155/2016/7015626 |
| spellingShingle | Mario Solis-Paredes Salvador Espino y Sosa Guadalupe Estrada-Gutierrez Sonia Nava-Salazar Veronica Ortega-Castillo Mario Rodriguez-Bosch Eyerahi Bravo-Flores Aurora Espejel-Nuñez Maricruz Tolentino-Dolores Rubí Gaona-Estudillo Nancy Martinez-Bautista Otilia Perichart-Perera Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity International Journal of Endocrinology |
| title | Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity |
| title_full | Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity |
| title_fullStr | Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity |
| title_full_unstemmed | Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity |
| title_short | Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity |
| title_sort | maternal and fetal lipid and adipokine profiles and their association with obesity |
| url | http://dx.doi.org/10.1155/2016/7015626 |
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