Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients
A great disappointment in head and neck cancer surgery is that 10–30% of head and neck squamous cell carcinoma (HNSCC) patients develop local recurrences despite histopathologically tumor-free surgical margins. These recurrences result from either minimal residual cancer (MRC) or preneoplastic lesio...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0474 |
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| _version_ | 1832563947612405760 |
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| author | A. Peggy Graveland Michiel de Maaker Boudewijn J. M. Braakhuis Remco de Bree Simone E. J. Eerenstein Elisabeth Bloemena C. René Leemans Ruud H. Brakenhoff |
| author_facet | A. Peggy Graveland Michiel de Maaker Boudewijn J. M. Braakhuis Remco de Bree Simone E. J. Eerenstein Elisabeth Bloemena C. René Leemans Ruud H. Brakenhoff |
| author_sort | A. Peggy Graveland |
| collection | DOAJ |
| description | A great disappointment in head and neck cancer surgery is that 10–30% of head and neck squamous cell carcinoma (HNSCC) patients develop local recurrences despite histopathologically tumor-free surgical margins. These recurrences result from either minimal residual cancer (MRC) or preneoplastic lesions that remain behind after tumor resection. Distinguishing MRC from preneoplasic lesions is important to tailor postoperative radiotherapy more adequately. Here we investigated the suitability of quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) using human Ly-6D (hLy-6D) transcripts as molecular marker to detect MRC in surgical margins. |
| format | Article |
| id | doaj-art-e20bc508bf6b4c31bce1690884501b5d |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-e20bc508bf6b4c31bce1690884501b5d2025-02-03T01:12:16ZengWileyCellular Oncology1570-58701875-86062009-01-0131431732810.3233/CLO-2009-0474Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer PatientsA. Peggy Graveland0Michiel de Maaker1Boudewijn J. M. Braakhuis2Remco de Bree3Simone E. J. Eerenstein4Elisabeth Bloemena5C. René Leemans6Ruud H. Brakenhoff7Department of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsA great disappointment in head and neck cancer surgery is that 10–30% of head and neck squamous cell carcinoma (HNSCC) patients develop local recurrences despite histopathologically tumor-free surgical margins. These recurrences result from either minimal residual cancer (MRC) or preneoplastic lesions that remain behind after tumor resection. Distinguishing MRC from preneoplasic lesions is important to tailor postoperative radiotherapy more adequately. Here we investigated the suitability of quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) using human Ly-6D (hLy-6D) transcripts as molecular marker to detect MRC in surgical margins.http://dx.doi.org/10.3233/CLO-2009-0474 |
| spellingShingle | A. Peggy Graveland Michiel de Maaker Boudewijn J. M. Braakhuis Remco de Bree Simone E. J. Eerenstein Elisabeth Bloemena C. René Leemans Ruud H. Brakenhoff Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients Cellular Oncology |
| title | Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients |
| title_full | Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients |
| title_fullStr | Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients |
| title_full_unstemmed | Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients |
| title_short | Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients |
| title_sort | molecular detection of minimal residual cancer in surgical margins of head and neck cancer patients |
| url | http://dx.doi.org/10.3233/CLO-2009-0474 |
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