Dermal white adipose tissue: A new modulator in wound healing and regeneration
Dermal white adipose tissue (dWAT), distinguished by its origin from cells within the dermis and independence from subcutaneous fat tissue, has garnered significant attention for its non-metabolic functions. Characterized by strong communication with other components of the skin, dWAT mediates the p...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424002086 |
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| author | Zhongyu Wu Zhanqi Wang Tao Chen Dongyang Wang Feng Zhou Guorui Zhang Shan Wei Yingying Wu |
| author_facet | Zhongyu Wu Zhanqi Wang Tao Chen Dongyang Wang Feng Zhou Guorui Zhang Shan Wei Yingying Wu |
| author_sort | Zhongyu Wu |
| collection | DOAJ |
| description | Dermal white adipose tissue (dWAT), distinguished by its origin from cells within the dermis and independence from subcutaneous fat tissue, has garnered significant attention for its non-metabolic functions. Characterized by strong communication with other components of the skin, dWAT mediates the proliferation and recruitment of various cell types by releasing adipogenic and inflammatory factors. Here, we focus on the modulatory role of dWAT at different stages during wound healing, highlighting its ability to mediate the adipocyte-to-myofibroblast transition which plays a pivotal role in the physiology and pathology processes of skin fibrosis, scarring, and aging. This review highlights the regulatory potential of dWAT in modulating wound healing processes and presents it as a target for developing therapeutic strategies aimed at reducing scarring and enhancing regenerative outcomes in skin-related disorders. |
| format | Article |
| id | doaj-art-e1fbb1ec34bb4edd92d1cd9684ba2f83 |
| institution | DOAJ |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-e1fbb1ec34bb4edd92d1cd9684ba2f832025-08-20T02:58:29ZengElsevierRegenerative Therapy2352-32042025-03-012811512510.1016/j.reth.2024.11.015Dermal white adipose tissue: A new modulator in wound healing and regenerationZhongyu Wu0Zhanqi Wang1Tao Chen2Dongyang Wang3Feng Zhou4Guorui Zhang5Shan Wei6Yingying Wu7Department of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR ChinaDepartment of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081, PR ChinaDepartment of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR ChinaDepartment of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR ChinaDepartment of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR ChinaHuizhou Health Sciences Polytechnic, Huizhou 516025, Guangdong, PR ChinaDepartment of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China; Corresponding author. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, and Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, 14 Third Section, Renmin Nan Road, Chengdu 610041, PR China.Dermal white adipose tissue (dWAT), distinguished by its origin from cells within the dermis and independence from subcutaneous fat tissue, has garnered significant attention for its non-metabolic functions. Characterized by strong communication with other components of the skin, dWAT mediates the proliferation and recruitment of various cell types by releasing adipogenic and inflammatory factors. Here, we focus on the modulatory role of dWAT at different stages during wound healing, highlighting its ability to mediate the adipocyte-to-myofibroblast transition which plays a pivotal role in the physiology and pathology processes of skin fibrosis, scarring, and aging. This review highlights the regulatory potential of dWAT in modulating wound healing processes and presents it as a target for developing therapeutic strategies aimed at reducing scarring and enhancing regenerative outcomes in skin-related disorders.http://www.sciencedirect.com/science/article/pii/S2352320424002086Wound healingDermal white adipose tissueSkinRegeneration |
| spellingShingle | Zhongyu Wu Zhanqi Wang Tao Chen Dongyang Wang Feng Zhou Guorui Zhang Shan Wei Yingying Wu Dermal white adipose tissue: A new modulator in wound healing and regeneration Regenerative Therapy Wound healing Dermal white adipose tissue Skin Regeneration |
| title | Dermal white adipose tissue: A new modulator in wound healing and regeneration |
| title_full | Dermal white adipose tissue: A new modulator in wound healing and regeneration |
| title_fullStr | Dermal white adipose tissue: A new modulator in wound healing and regeneration |
| title_full_unstemmed | Dermal white adipose tissue: A new modulator in wound healing and regeneration |
| title_short | Dermal white adipose tissue: A new modulator in wound healing and regeneration |
| title_sort | dermal white adipose tissue a new modulator in wound healing and regeneration |
| topic | Wound healing Dermal white adipose tissue Skin Regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424002086 |
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