Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments
Abstract The World Health Organization has confirmed that asbestos fibres are carcinogenic, claiming that asbestos-related diseases should be eradicated worldwide. Actinolite, amosite, anthophyllite, chrysotile, crocidolite, and tremolite are regulated asbestiform mineral phases. However, in nature,...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86325-z |
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| author | Sebastiano La Maestra Gaia M. Militello Stefano Alberti Mirko Benvenuti Laura Gaggero |
| author_facet | Sebastiano La Maestra Gaia M. Militello Stefano Alberti Mirko Benvenuti Laura Gaggero |
| author_sort | Sebastiano La Maestra |
| collection | DOAJ |
| description | Abstract The World Health Organization has confirmed that asbestos fibres are carcinogenic, claiming that asbestos-related diseases should be eradicated worldwide. Actinolite, amosite, anthophyllite, chrysotile, crocidolite, and tremolite are regulated asbestiform mineral phases. However, in nature, asbestos minerals occur either in a fibrous and asbestiform (original morphology characterized by high length-to-width ratio and provided of high tensile strength and flexibility) or fibrous but not asbestiform appearance. This study used human epithelial cancer cells (A549) and a mouse fibroblast cell line (Balb/c 3T3) to compare the genotoxic and carcinogenic effects of a sample of amphibole asbestos with samples of fibrous not asbestiform named cleavage fragments (CV) obtained by grinding non-asbestiform amphiboles. The results showed that exposure of alveolar lung cells to asbestos and elongated mineral particles, in the habit of cleavage fragments (CF) derived from the grinding of non-asbestiform amphiboles and serpentines, causes cytotoxic effects, oxidative stress and genotoxic damage. Moreover, CF obtained from an actinolite schist induces a transformation effect in the Balb/c 3T3 model. Together, these findings highlight the importance of considering CF as a potential threat to human health since it can cause genotoxic damage by triggering cellular transformation processes that overlap with the mechanisms involved in the carcinogenesis processes of asbestos. |
| format | Article |
| id | doaj-art-e1f57279f432479d8ee16847e3d43077 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
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| spelling | doaj-art-e1f57279f432479d8ee16847e3d430772025-02-02T12:21:12ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-86325-zEvaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragmentsSebastiano La Maestra0Gaia M. Militello1Stefano Alberti2Mirko Benvenuti3Laura Gaggero4Department of Health Sciences, University of GenoaDepartment of Earth, Environment and Life Sciences, University of GenoaDepartment of Chemistry and Industrial Chemistry, University of GenoaDepartment of Health Sciences, University of GenoaDepartment of Earth, Environment and Life Sciences, University of GenoaAbstract The World Health Organization has confirmed that asbestos fibres are carcinogenic, claiming that asbestos-related diseases should be eradicated worldwide. Actinolite, amosite, anthophyllite, chrysotile, crocidolite, and tremolite are regulated asbestiform mineral phases. However, in nature, asbestos minerals occur either in a fibrous and asbestiform (original morphology characterized by high length-to-width ratio and provided of high tensile strength and flexibility) or fibrous but not asbestiform appearance. This study used human epithelial cancer cells (A549) and a mouse fibroblast cell line (Balb/c 3T3) to compare the genotoxic and carcinogenic effects of a sample of amphibole asbestos with samples of fibrous not asbestiform named cleavage fragments (CV) obtained by grinding non-asbestiform amphiboles. The results showed that exposure of alveolar lung cells to asbestos and elongated mineral particles, in the habit of cleavage fragments (CF) derived from the grinding of non-asbestiform amphiboles and serpentines, causes cytotoxic effects, oxidative stress and genotoxic damage. Moreover, CF obtained from an actinolite schist induces a transformation effect in the Balb/c 3T3 model. Together, these findings highlight the importance of considering CF as a potential threat to human health since it can cause genotoxic damage by triggering cellular transformation processes that overlap with the mechanisms involved in the carcinogenesis processes of asbestos.https://doi.org/10.1038/s41598-025-86325-zElongated mineral particlesCleavage fragmentsNon-asbestiform amphibolesFibresGenotoxicity and oxidative stressCarcinogenic potential |
| spellingShingle | Sebastiano La Maestra Gaia M. Militello Stefano Alberti Mirko Benvenuti Laura Gaggero Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments Scientific Reports Elongated mineral particles Cleavage fragments Non-asbestiform amphiboles Fibres Genotoxicity and oxidative stress Carcinogenic potential |
| title | Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments |
| title_full | Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments |
| title_fullStr | Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments |
| title_full_unstemmed | Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments |
| title_short | Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments |
| title_sort | evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments |
| topic | Elongated mineral particles Cleavage fragments Non-asbestiform amphiboles Fibres Genotoxicity and oxidative stress Carcinogenic potential |
| url | https://doi.org/10.1038/s41598-025-86325-z |
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