Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments
Abstract The World Health Organization has confirmed that asbestos fibres are carcinogenic, claiming that asbestos-related diseases should be eradicated worldwide. Actinolite, amosite, anthophyllite, chrysotile, crocidolite, and tremolite are regulated asbestiform mineral phases. However, in nature,...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-86325-z |
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| Summary: | Abstract The World Health Organization has confirmed that asbestos fibres are carcinogenic, claiming that asbestos-related diseases should be eradicated worldwide. Actinolite, amosite, anthophyllite, chrysotile, crocidolite, and tremolite are regulated asbestiform mineral phases. However, in nature, asbestos minerals occur either in a fibrous and asbestiform (original morphology characterized by high length-to-width ratio and provided of high tensile strength and flexibility) or fibrous but not asbestiform appearance. This study used human epithelial cancer cells (A549) and a mouse fibroblast cell line (Balb/c 3T3) to compare the genotoxic and carcinogenic effects of a sample of amphibole asbestos with samples of fibrous not asbestiform named cleavage fragments (CV) obtained by grinding non-asbestiform amphiboles. The results showed that exposure of alveolar lung cells to asbestos and elongated mineral particles, in the habit of cleavage fragments (CF) derived from the grinding of non-asbestiform amphiboles and serpentines, causes cytotoxic effects, oxidative stress and genotoxic damage. Moreover, CF obtained from an actinolite schist induces a transformation effect in the Balb/c 3T3 model. Together, these findings highlight the importance of considering CF as a potential threat to human health since it can cause genotoxic damage by triggering cellular transformation processes that overlap with the mechanisms involved in the carcinogenesis processes of asbestos. |
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| ISSN: | 2045-2322 |